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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1994-9-14
|
| pubmed:abstractText |
Immunoreactivity for CD23, a B-cell activation antigen, was compared in 22 cases of B-cell small lymphocytic lymphoma (SLL)/chronic lymphocytic leukemia (CLL) and 15 cases of mantle cell lymphoma (MCL) (intermediate lymphocytic lymphoma or centrocytic lymphoma) to determine if the presence of this antigen can be used as a criterion to distinguish between these two low-grade B-cell lymphoproliferative processes. CD23 immunoreactivity was observed in 21 of 22 cases (95%) of SLL/CLL, whereas only 2 of 15 cases (13%) of MCL were reactive for this antigen; therefore, lack of CD23 reactivity is statistically significantly associated with MCL (P < 0.0001). In addition, lack of CD23 immunoreactivity is also statistically significantly associated with SLL with plasmacytoid differentiation in comparison with typical SLL (P < 0.0003), although only a small number of cases were evaluated. SLL/CLL, MCL, and SLL with plasmacytoid differentiation cases were all uniformly immunoreactive for pan-B-cell antigens such as CD20 and CD22. Immunoreactivity for CD23 appears to be a useful marker to aid in distinguishing SLL/CLL from MCL and may be helpful in routine immunophenotypic screening of low-grade B-cell derived lymphoproliferative processes.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0893-3952
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
7
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
326-31
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:8058704-Adult,
pubmed-meshheading:8058704-Aged,
pubmed-meshheading:8058704-Aged, 80 and over,
pubmed-meshheading:8058704-Female,
pubmed-meshheading:8058704-Humans,
pubmed-meshheading:8058704-Immunoenzyme Techniques,
pubmed-meshheading:8058704-Immunophenotyping,
pubmed-meshheading:8058704-Leukemia, Lymphocytic, Chronic, B-Cell,
pubmed-meshheading:8058704-Male,
pubmed-meshheading:8058704-Middle Aged,
pubmed-meshheading:8058704-Receptors, IgE,
pubmed-meshheading:8058704-Tumor Markers, Biological
|
| pubmed:year |
1994
|
| pubmed:articleTitle |
Distinction between small lymphocytic and mantle cell lymphoma by immunoreactivity for CD23.
|
| pubmed:affiliation |
Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts.
|
| pubmed:publicationType |
Journal Article
|