Linked Life Data

8057

Source:http://linkedlifedata.com/resource/pubmed/id/8057

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1976-10-2
pubmed:abstractText
1-(2-Methoxy-2-phenyl)-ethyl-4-(2-hydroxy-3-methoxy-3-phenyl)-propyl-iperazine-dihydrochloride (zipeprol, Respilene) is a substance of non-phenanthrenic chemical structure. In the cat, it antagonised cough induced by stimulation of the superior laryngeal nerve or by direct mechanical excitation of the sensitive tracheo-bronchial receptors. The efficacy of zipeprol after enteral administration made it possible both to establish good intestinal absorption and to rank it favourably in relation to several major antitussive reference products; codeine, codethyline, dextromethorphan, diphenhydramine and pentoxyverine. The activity of zipeprol was superior or equal to that of all these substances, excdept codeine. The antitussive properties appeared to be due to a central action. Other properties have been demonstrated which suggest at least a supplementary mechanism in the inhibition of cough, in addition to the central action. These consisted of slight antihistamine and anticholinergic properties, marked local-anesthetic potency and bronchospasmolytic activity. This latter property was demonstrated by the inhibition of histamine and serotonin induced bronchospasm in the guinea-pig. In vitro, using human sputum, zipeprol had a mucolytic action, shown by a decrease in sputum vis viscosity and lysis of DNA and AMPS fibrils. In the dog, at high doses, zipeprol unlike codeine, did not inhibit central stimulation of respiration by hypercapnia, in addition no modification of ventilatory dynamics or blood gases was seen. On the basis of these results, zipeprol can be considered as possessing no respiratory depressant effect even in the upper ranges of its antitussive doses.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0004-4172
pubmed:author
pubmed:issnType
Print
pubmed:volume
26
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
523-30
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:8057-Administration, Oral, pubmed-meshheading:8057-Anesthetics, Local, pubmed-meshheading:8057-Animals, pubmed-meshheading:8057-Antitussive Agents, pubmed-meshheading:8057-Bronchi, pubmed-meshheading:8057-Cats, pubmed-meshheading:8057-Codeine, pubmed-meshheading:8057-Cough, pubmed-meshheading:8057-Dextromethorphan, pubmed-meshheading:8057-Diphenhydramine, pubmed-meshheading:8057-Dogs, pubmed-meshheading:8057-Expectorants, pubmed-meshheading:8057-Female, pubmed-meshheading:8057-Guinea Pigs, pubmed-meshheading:8057-Histamine H1 Antagonists, pubmed-meshheading:8057-Humans, pubmed-meshheading:8057-Injections, Intravenous, pubmed-meshheading:8057-Lethal Dose 50, pubmed-meshheading:8057-Male, pubmed-meshheading:8057-Mice, pubmed-meshheading:8057-Muscle, Smooth, pubmed-meshheading:8057-Muscle Contraction, pubmed-meshheading:8057-Parasympatholytics, pubmed-meshheading:8057-Piperazines, pubmed-meshheading:8057-Rats, pubmed-meshheading:8057-Respiration
pubmed:year
1976
pubmed:articleTitle
General pharmacological properties of a new non-opiate antitussive: zipeprol (3024 CERM). I. Action on respiratory function and acute toxicity.
pubmed:publicationType
Journal Article, Comparative Study, In Vitro