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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
|
pubmed:dateCreated |
1994-9-14
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pubmed:abstractText |
Focal cerebral ischemia causes rapid intensity changes in diffusion-weighted images (DWI) and elevated lactate as detected by localized proton spectroscopy (1H-MRS). To investigate whether such changes can also be evoked by perischemic depolarizations, we combined DWI and 1H-MRS measurements with DC potential recordings. About 40 min after occlusion of the middle cerebral artery in a rat, a negative DC deflection was observed indicating transient cell depolarization. Coincidentally with the depolarization a transient increase of the DWI signal intensity and a partially reversible increase of lactate occurred in the periphery of the ischemic territory. These results show that peri-ischemic depolarization, known to contribute to the evolution of cerebral infarction, evokes disturbances that can be detected by DWI and 1H-MRS.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Mar
|
pubmed:issn |
0740-3194
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
31
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pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
337-41
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading | |
pubmed:year |
1994
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pubmed:articleTitle |
Transient cell depolarization after permanent middle cerebral artery occlusion: an observation by diffusion-weighted MRI and localized 1H-MRS.
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pubmed:affiliation |
Max-Planck-Institut für neurologische Forschung, Abteilung für experimentelle Neurologie, Köln F. R. Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|