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rdf:type |
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lifeskim:mentions |
umls-concept:C0023721,
umls-concept:C0031760,
umls-concept:C0035499,
umls-concept:C0086805,
umls-concept:C0205171,
umls-concept:C0456389,
umls-concept:C0871261,
umls-concept:C1519193,
umls-concept:C1551359,
umls-concept:C1704448,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2827666,
umls-concept:C2911692
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pubmed:issue |
4
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pubmed:dateCreated |
1994-9-13
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pubmed:abstractText |
Limulus ventral photoreceptors generate highly variable responses to the absorption of single photons. We have obtained data on the size distribution of these responses, derived the distribution predicted from simple transduction cascade models and compared the theory and data. In the simplest of models, the active state of the visual pigment (defined by its ability to activate G protein) is turned off in a single reaction. The output of such a cascade is predicted to be highly variable, largely because of stochastic variation in the number of G proteins activated. The exact distribution predicted is exponential, but we find that an exponential does not adequately account for the data. The data agree much better with the predictions of a cascade model in which the active state of the visual pigment is turned off by a multi-step process.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8057085-1181378,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8057085-14100964,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8057085-14205019,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8057085-14225259,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8057085-1689056,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8057085-2158671,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8057085-2419481,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8057085-2423011,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8057085-2498877,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8057085-3006038,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8057085-3855544,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8057085-3981127,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8057085-4705637,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8057085-5071400,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8057085-5122373,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8057085-5483105,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8057085-5664231,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8057085-5806593,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8057085-6089868,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8057085-6436059,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8057085-6980670,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8057085-978587
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0022-1295
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
103
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
691-726
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:8057085-Animals,
pubmed-meshheading:8057085-Electrophysiology,
pubmed-meshheading:8057085-GTP-Binding Proteins,
pubmed-meshheading:8057085-Horseshoe Crabs,
pubmed-meshheading:8057085-Models, Biological,
pubmed-meshheading:8057085-Photons,
pubmed-meshheading:8057085-Photoreceptor Cells, Invertebrate,
pubmed-meshheading:8057085-Probability,
pubmed-meshheading:8057085-Quantum Theory,
pubmed-meshheading:8057085-Rhodopsin,
pubmed-meshheading:8057085-Signal Transduction
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pubmed:year |
1994
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pubmed:articleTitle |
Multi-step rhodopsin inactivation schemes can account for the size variability of single photon responses in Limulus ventral photoreceptors.
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pubmed:affiliation |
Department of Biology, Brandeis University, Waltham, Massachusetts 02254.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.
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