Linked Life Data

8055353

Source:http://linkedlifedata.com/resource/pubmed/id/8055353

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1994-9-12
pubmed:abstractText
This study examined the effects of kainic, ibotenic, and quisqualic acid-induced lesions of the rat striatum on biochemical markers of the glutamatergic corticostriatal and dopaminergic nigrostriatal afferent transmissions. Fifteen to 21 days after striatal injections of these various compounds, significant reductions in the high-affinity glutamate uptake rate, due to decreases in the Vmax of the transport process, were measured. Interestingly, the relationship between these decreases in the Vmax and the decreases in the levels of biochemical markers for the intrinsic striatal cholinergic and GABAergic neurons differed depending on the excitotoxin used. These findings suggest that excitatory amino acid agonists-induced alterations of the glutamatergic terminal activity may not depend only on the loss of cholinergic and GABAergic striatal neurons. In contrast, the observed changes in the dopamine and metabolite contents seemed to be related to the extent of the striatal neuronal degeneration induced by each excitotoxin. All in all, these results indicate that excitatory amino acid agonists can impair the activity and/or the integrity of the two main striatal afferent pathways, through presumably different mechanisms.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0361-9230
pubmed:author
pubmed:issnType
Print
pubmed:volume
34
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
291-300
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Local injections of excitatory amino acid agonists alter the glutamatergic and dopaminergic transmissions in the rat striatum.
pubmed:affiliation
Laboratoire de Neurobiologie Cellulaire et Fonctionnelle, CNRS, Marseille, France.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't