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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1994-9-12
|
| pubmed:abstractText |
Skeletal muscle ventricles (SMVs) were constructed from the latissimus dorsi muscle in 12 dogs. In group I (n = 6), SMVs were placed intrathoracic, in the apex of the left hemithorax. In group II (n = 6), SMVs were positioned extrathoracic between the chest wall and subcutaneous tissue. After a 3-week vascular delay period, SMVs were electrically pre-conditioned with 2-Hz continuous stimulation for 6 weeks. At a second procedure, a valved conduit was placed between the left ventricular (LV) apex and the SMV, and a second valved conduit between the SMV and the thoracic aorta. The SMVs were stimulated to contract during diastole at a 1:2 ratio with the heart. In group I, SMVs generated peak pressures of 91 +/- 10 mmHg, pumped 47% of the systemic blood flow (0.73 +/- 0.25 vs 1.54 +/- 0.42 L/min; p < 0.05), and produced a 25% decrease in the LV systolic tension-time index (TTI) (16.9 +/- 2.7 vs 12.5 +/- 3.3 mmHg.sec; p < 0.05). In group II, SMV peak pressure was 93 +/- 10 mmHg, SMVs pumped 51% of the systemic blood flow (0.78 +/- 0.10 vs 1.53 +/- 0.42 L/min; p < 0.05), and the LV systolic TTI decreased 29% (14.0 +/- 0.8 vs 9.9 +/- 2.0 mmHg.sec; p < 0.05). There was no significant difference between group I and II. These data indicate that the SMV:LV apex-to-aorta configuration is the most effective method reported to date for skeletal muscle cardiac assist. Extrathoracic and intrathoracic SMVs functioned equally well after connection to the circulation.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0886-0440
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
9
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
332-42
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:8054728-Anastomosis, Surgical,
pubmed-meshheading:8054728-Animals,
pubmed-meshheading:8054728-Aorta, Thoracic,
pubmed-meshheading:8054728-Assisted Circulation,
pubmed-meshheading:8054728-Blood Pressure,
pubmed-meshheading:8054728-Blood Vessel Prosthesis,
pubmed-meshheading:8054728-Cardiac Output,
pubmed-meshheading:8054728-Dogs,
pubmed-meshheading:8054728-Electrodes, Implanted,
pubmed-meshheading:8054728-Follow-Up Studies,
pubmed-meshheading:8054728-Heart Ventricles,
pubmed-meshheading:8054728-Hemodynamics,
pubmed-meshheading:8054728-Muscle Contraction,
pubmed-meshheading:8054728-Muscles,
pubmed-meshheading:8054728-Polyethylene Terephthalates,
pubmed-meshheading:8054728-Polytetrafluoroethylene,
pubmed-meshheading:8054728-Pulmonary Artery,
pubmed-meshheading:8054728-Regional Blood Flow,
pubmed-meshheading:8054728-Stroke Volume,
pubmed-meshheading:8054728-Surgical Flaps,
pubmed-meshheading:8054728-Thoracic Surgery,
pubmed-meshheading:8054728-Ventricular Pressure
|
| pubmed:year |
1994
|
| pubmed:articleTitle |
Intrathoracic and extrathoracic skeletal muscle ventricles in circulation: left ventricular apex-to-aorta configuration.
|
| pubmed:affiliation |
Department of Surgery, Wayne State University, Detroit, Michigan 48225.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.
|