Linked Life Data

8054313

Source:http://linkedlifedata.com/resource/pubmed/id/8054313

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1994-9-13
pubmed:abstractText
While the symptoms of schizophrenia can be grouped into positive and negative syndromes, increasing evidence suggests that three clusters of symptoms are present. Liddle (1987a) described a three-syndrome model comprised of reality distortion, psychomotor poverty and disorganization symptom clusters. This model was assessed in the present study using a sample of 72 members of five families segregating schizophrenia. A wide range of psychopathology was present across a spectrum of diagnoses. Data on symptoms used in Liddle's model were derived from the Positive and Negative Syndrome Scale (PANSS) and a mental status examination. Factor analysis of the data indicated the presence of three clusters of symptoms. The psychomotor poverty or negative symptom cluster was confirmed in the familial sample. However, the other two factors differed somewhat from the Liddle model. Hallucinations, delusions, disorganized thinking and inappropriate affect formed one factor; suspiciousness and stereotyped thinking formed the other. These three symptom clusters may be comparable to the catatonic, hebephrenic and paranoid classical subtypes of schizophrenia. The implications of Liddle's model for genetic studies of schizophrenia require further investigation.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0920-9964
pubmed:author
pubmed:issnType
Print
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
213-21
pubmed:dateRevised
2011-10-31
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Testing Liddle's three-syndrome model in families with schizophrenia.
pubmed:affiliation
Department of Psychiatry, University of Toronto, Ont., Canada.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't