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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1994-9-13
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pubmed:abstractText |
A study was designed to determine whether oesophageal carcinomas can be induced through reflux of duodenal contents. Male Wistar rats weighing 230-250 g were divided into three groups according to the surgical procedure performed: (1) the duodenal contents were directed into the forestomach through a stoma (duodeno-forestomach reflux); (2) the duodenal contents were regurgitated into the forestomach through the glandular stomach (duodeno-glandular-forestomach reflux); and (3) a sham operation was performed as a control. Animals were fed standard CRF-1 solid food and tap water that was not exposed to carcinogens and were sacrificed 50 weeks post-operatively. While no neoplasia was observed in any of the 32 control rats, 4/11 (36%) with duodeno-forestomach reflux and 3/18 (17%) animals with duodeno-glandular-forestomach reflux developed carcinomas in the lower oesophagus and forestomach. The incidence in each group was significantly higher than in the controls (P < 0.01 and P < 0.05 respectively). Six of the seven lesions consisted of squamous cell carcinomas, and one was a mucinous adenocarcinoma. Oesophageal columnar epithelial metaplasia was observed in two (18%) of the animals with duodeno-forestomach reflux. Carcinomas were always surrounded by chronic inflammatory changes, including regenerative thickening, basal cell hyperplasia and dysplasia. Additional well-differentiated adenocarcinomas were observed in the prepyloric antrum of 6/18 (33%) animals with duodeno-glandular-forestomach reflux. These findings indicate that chronic reflux of duodenal contents may cause oesophageal carcinoma.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8054264-10483471,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8054264-1186274,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8054264-1211042,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8054264-1347663,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8054264-1517278,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8054264-1598670,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8054264-1773946,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8054264-1937962,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8054264-2342371,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8054264-2344809,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8054264-2799652,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8054264-2819720,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8054264-3183331,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8054264-3395818,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8054264-3505512,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8054264-3608927,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8054264-3697920,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8054264-3768649,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8054264-3966964,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/8054264-4040033,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/8054264-6526634,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/8054264-89331
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0007-0920
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
70
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
185-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:8054264-Adenocarcinoma, Mucinous,
pubmed-meshheading:8054264-Animals,
pubmed-meshheading:8054264-Carcinoma, Squamous Cell,
pubmed-meshheading:8054264-Duodenogastric Reflux,
pubmed-meshheading:8054264-Esophageal Neoplasms,
pubmed-meshheading:8054264-Esophagus,
pubmed-meshheading:8054264-Gastrointestinal Contents,
pubmed-meshheading:8054264-Hyperplasia,
pubmed-meshheading:8054264-Male,
pubmed-meshheading:8054264-Rats,
pubmed-meshheading:8054264-Rats, Wistar,
pubmed-meshheading:8054264-Stomach,
pubmed-meshheading:8054264-Stomach Neoplasms
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pubmed:year |
1994
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pubmed:articleTitle |
Induction of oesophageal and forestomach carcinomas in rats by reflux of duodenal contents.
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pubmed:affiliation |
School of Medicine, Kanazawa University, Japan.
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pubmed:publicationType |
Journal Article
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