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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
16
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pubmed:dateCreated |
1994-9-2
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pubmed:abstractText |
The p21 region of human chromosome 9 is thought to contain a gene (MLM) involved in genetic susceptibility to melanoma and a gene or genes that influence progression of certain other tumors. Genomic clones that span a large region in 9p21 surrounding the presumptive tumor suppressor gene(s) have been isolated. A set of sequence-tagged sites in this region has been developed. By using these markers and others previously reported, the 9p21 region has been studied by physical mapping in 84 melanoma cell lines. A putative tumor suppressor gene, perhaps MLM itself, has been localized to a region of less than 40 kb that lies proximal (centromeric) to the alpha-interferon gene cluster.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8052620-1301184,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8052620-1438246,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8052620-1439824,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8052620-1568221,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8052620-1886420,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8052620-2177644,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8052620-2372499,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8052620-2654303,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8052620-3134658,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8052620-388356,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8052620-7683574,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8052620-8213823,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8052620-8219760,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8052620-8259213
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
2
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pubmed:volume |
91
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
7563-7
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:8052620-Chromosome Mapping,
pubmed-meshheading:8052620-Chromosomes, Artificial, Yeast,
pubmed-meshheading:8052620-Chromosomes, Human, Pair 9,
pubmed-meshheading:8052620-Cloning, Molecular,
pubmed-meshheading:8052620-Genes, Tumor Suppressor,
pubmed-meshheading:8052620-Genetic Linkage,
pubmed-meshheading:8052620-Genetic Markers,
pubmed-meshheading:8052620-Homozygote,
pubmed-meshheading:8052620-Humans,
pubmed-meshheading:8052620-Melanoma,
pubmed-meshheading:8052620-Sequence Deletion,
pubmed-meshheading:8052620-Sequence Tagged Sites,
pubmed-meshheading:8052620-Tumor Cells, Cultured
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pubmed:year |
1994
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pubmed:articleTitle |
Localization of a putative tumor suppressor gene by using homozygous deletions in melanomas.
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pubmed:affiliation |
Myriad Genetics, Inc., Salt Lake City, UT 84108.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.
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