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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1994-9-6
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pubmed:abstractText |
To identify the inhibitor of prednisolone metabolism contained in Saiboku-To, we conducted in-vitro experiments of 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD), using rat liver homogenate and cortisol as a typical substrate. We studied the effects of ten herbal constituents on 11 beta-HSD. Five herbal extracts showed inhibitory activity with Glycyrrhiza glabra > Perillae frutescens > Zizyphus vulgaris > Magnolia officinalis > Scutellaria baicalensis. This suggests that unknown 11 beta-HSD inhibitors are contained in four herbs other than G. glabra which contains a known inhibitor, glycyrrhizin (and glycyrrhetinic acid). Seven chemical constituents which have been identified as the major urinary products of Saiboku-To in healthy and asthmatic subjects were studied; magnolol derived from M. officinalis showed the most potent inhibition of the enzyme (IC50, 1.8 x 10(-4) M). Although this activity was less than that of glycyrrhizin, the inhibition mechanism (non-competitive) was different from a known competitive mechanism. These results suggest that magnolol might contribute to the inhibitory effects of Saiboku-To on prednisolone metabolism through inhibition of 11 beta-HSD.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/11-beta-Hydroxysteroid...,
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents, Phytogenic,
http://linkedlifedata.com/resource/pubmed/chemical/Biphenyl Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Cortisone,
http://linkedlifedata.com/resource/pubmed/chemical/Drugs, Chinese Herbal,
http://linkedlifedata.com/resource/pubmed/chemical/Glucocorticoids,
http://linkedlifedata.com/resource/pubmed/chemical/Glycyrrhetinic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Glycyrrhizic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Hydrocortisone,
http://linkedlifedata.com/resource/pubmed/chemical/Hydroxysteroid Dehydrogenases,
http://linkedlifedata.com/resource/pubmed/chemical/Immunosuppressive Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Lignans,
http://linkedlifedata.com/resource/pubmed/chemical/honokiol,
http://linkedlifedata.com/resource/pubmed/chemical/magnolol,
http://linkedlifedata.com/resource/pubmed/chemical/saiboku-to
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0022-3573
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
46
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
305-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8051615-11-beta-Hydroxysteroid Dehydrogenases,
pubmed-meshheading:8051615-Animals,
pubmed-meshheading:8051615-Antineoplastic Agents, Phytogenic,
pubmed-meshheading:8051615-Asthma,
pubmed-meshheading:8051615-Biphenyl Compounds,
pubmed-meshheading:8051615-Chromatography, High Pressure Liquid,
pubmed-meshheading:8051615-Cortisone,
pubmed-meshheading:8051615-Dose-Response Relationship, Drug,
pubmed-meshheading:8051615-Drugs, Chinese Herbal,
pubmed-meshheading:8051615-Glucocorticoids,
pubmed-meshheading:8051615-Glycyrrhetinic Acid,
pubmed-meshheading:8051615-Glycyrrhizic Acid,
pubmed-meshheading:8051615-Hydrocortisone,
pubmed-meshheading:8051615-Hydroxysteroid Dehydrogenases,
pubmed-meshheading:8051615-Immunosuppressive Agents,
pubmed-meshheading:8051615-Lignans,
pubmed-meshheading:8051615-Liver,
pubmed-meshheading:8051615-Male,
pubmed-meshheading:8051615-Medicine, Kampo,
pubmed-meshheading:8051615-Rats,
pubmed-meshheading:8051615-Rats, Wistar
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pubmed:year |
1994
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pubmed:articleTitle |
A novel 11 beta-hydroxysteroid dehydrogenase inhibitor contained in saiboku-to, a herbal remedy for steroid-dependent bronchial asthma.
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pubmed:affiliation |
Department of Clinical Pharmacology, Tokyo College of Pharmacy, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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