Linked Life Data

8050542

Source:http://linkedlifedata.com/resource/pubmed/id/8050542

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1994-9-7
pubmed:abstractText
We wished to find out if a deep inspiration had any influence on subsequent breathing which was mediated by neural rather than chemical stimuli. We therefore compared the effect on ventilation of a deep isocapnic breath with that of a similar breath containing 6% CO2, and with the effect of two successive tidal volume breaths of 6% CO2. We studied five normal subjects, each of whom repeated the three manoeuvres 20 times, and we used ensemble averaging to increase the signal-to-noise ratio. The isocapnic deep inspiration was followed by a significant inhibition of ventilation in the group in the second post-stimulus breath, and in 4 of the 5 subjects in first and second post-stimulus breaths. This was due to an increase in both inspiratory and expiratory time, with a variable effect on tidal volume. A similar initial ventilatory inhibition was seen in the response to a deep breath of 6% CO2. When the isocapnic response was subtracted from the hypercapnic response, the result was similar to that observed from two tidal volume breaths of 6% CO2. We conclude that a single deep inflation of the lungs in awake man inhibits subsequent ventilation by a neural mechanism, and that this may affect the CO2 response measured by single-breath techniques using such manoeuvres.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0903-1936
pubmed:author
pubmed:issnType
Print
pubmed:volume
7
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
869-74
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Isocapnic and small hypercapnic single-breath stimuli: evidence for an inhibitory inflation reflex in conscious man.
pubmed:affiliation
Dept of Medicine, St George's Hospital Medical School, London, UK.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't