Linked Life Data

8048412

Source:http://linkedlifedata.com/resource/pubmed/id/8048412

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8 Suppl
pubmed:dateCreated
1994-8-31
pubmed:abstractText
Celiac disease is the major nutrient-induced disease of the small intestine. The disease is traditionally characterized by villous atrophy responsive to gliadin. Recent data suggest that there is an extended spectrum of gluten sensitivity that includes first-degree relatives and patients with latent celiac disease. Genetic studies have identified HLA DQ A1 *0501 B1 *0201 as the predominant HLA gene most tightly linked to this condition. Gliadin-specific T cell clones restricted by DQ have now been identified in the small intestine lamina propria. Such T cells may be important in mediating many of the features of the disease. This review discusses the interrelationship of genetics, cereal chemistry, environmental factors, and immunology involved in the pathogenesis of celiac disease and explores its relationship with other nutrient-induced enteropathies.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0002-9270
pubmed:author
pubmed:issnType
Print
pubmed:volume
89
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
S2-17
pubmed:dateRevised
2009-9-29
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Celiac disease and other nutrient related injuries to the gastrointestinal tract.
pubmed:affiliation
Department of Clinical Medicine, Trinity College Dublin, Ireland.
pubmed:publicationType
Journal Article, Review