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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1994-8-30
|
| pubmed:abstractText |
Experimental evidence on the immunomodulating effects of ethanol is contradictory and, in animals, the immunological effects of long-term alcohol intake may depend on the age of animal, amount of alcohol consumed, and nutritional composition of the administered diet. In this study, immunological effects of pair-feeding a 35% ethanol-containing Bio-Serv liquid diet for 6 weeks were evaluated using two major histocompatibility complex (MHC)-compatible inbred strains of rats (F344 and LEW). Food intake, rate of gain in body weight, and percentages of B cells, T cells, and T cell subtypes were not affected by ethanol intake. Also, proliferative responses of lymphocytes to T and B cell mitogens were similar in control and ethanol-fed groups of the two strains. Ethanol consumption had no significant influence on spleen weights and the antibody plaque-forming cell (PFC) response in F344 rats; however, in LEW rats, ethanol ingestion leads to a significant decrease (about 16%; p < 0.012) in spleen weight and a > 75% reduction in the PFC response. These results suggest that a non-MHC-encoded gene(s) regulates the ethanol-mediated immunosuppression of the PFC response. Thus, LEW-F344 combination may provide an excellent model to characterize genetic factors which determine sensitivity/resistance to immunological effects of ethanol ingestion.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0041-008X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
127
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
37-43
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:8048051-Alcohol Drinking,
pubmed-meshheading:8048051-Animals,
pubmed-meshheading:8048051-Antibody Formation,
pubmed-meshheading:8048051-B-Lymphocytes,
pubmed-meshheading:8048051-Corticosterone,
pubmed-meshheading:8048051-Eating,
pubmed-meshheading:8048051-Ethanol,
pubmed-meshheading:8048051-Female,
pubmed-meshheading:8048051-Genes,
pubmed-meshheading:8048051-Immune Tolerance,
pubmed-meshheading:8048051-Liver,
pubmed-meshheading:8048051-Lymphocyte Activation,
pubmed-meshheading:8048051-Major Histocompatibility Complex,
pubmed-meshheading:8048051-Male,
pubmed-meshheading:8048051-Rats,
pubmed-meshheading:8048051-Rats, Inbred F344,
pubmed-meshheading:8048051-Rats, Inbred Lew,
pubmed-meshheading:8048051-Spleen,
pubmed-meshheading:8048051-T-Lymphocytes,
pubmed-meshheading:8048051-Weight Gain
|
| pubmed:year |
1994
|
| pubmed:articleTitle |
Alcohol-induced changes in the immune response: immunological effects of chronic ethanol intake are genetically regulated.
|
| pubmed:affiliation |
Immunotoxicology Section, Lovelace Institutes, Albuquerque, New Mexico 87108.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|