Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1994-8-30
pubmed:abstractText
Topically administered ophthalmic preparations can be associated with systemic adverse events if excessive absorption occurs. The nasolacrimal system can deliver eyedrops and ointments to the vascular nasal mucosae where the drugs are absorbed avoiding the first-pass effect and reaching sites of action with increased bioavailability. Topical ophthalmic eye-drop preparations most often involved include glaucoma medications, and diagnostic, antimicrobial and anti-inflammatory drugs. This article reviews reported systemic reactions and summarizes methods useful in preventing excessive absorption.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0015-4148
pubmed:author
pubmed:issnType
Print
pubmed:volume
81
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
256-60
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Systemic toxicity. Associated with topical ophthalmic medications.
pubmed:affiliation
University of California San Francisco Medical Center.
pubmed:publicationType
Journal Article, Review