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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1994-8-30
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pubmed:abstractText |
Natural killer (NK) cells kill normal and transformed hematopoietic cells that lack expression of major histocompatibility complex (MHC) class I antigens. Lysis of HLA-negative Epstein Barr virus-transformed B lymphoblastoid cell lines (B-LCL) by human NK cell clones can be inhibited by transfection of the target cells with certain HLA-A, -B, or -C alleles. NK cell clones established from an individual demonstrate clonal heterogeneity in HLA recognition and a single NK clone can recognize multiple alleles. We describe a potential human NK cell receptor (NKB1) for certain HLA-B alleles (e.g., HLA-B*5101 and-B*5801) identified by the mAb DX9. NKB1 is a 70-kD glycoprotein that is expressed on a subset of NK cells and NK cell clones. DX9 monoclonal antibody (mAb) specifically inhibits the interaction between NK cell clones and B-LCL targets transfected with certain HLA-B alleles, but does not affect recognition of HLA-A or HLA-C antigens. An individual NK cell clone can independently recognize B-LCL targets transfected with HLA-B or HLA-C antigens; however, DX9 mAb only affects interaction with transfectants expressing certain HLA-B alleles. These findings demonstrate the existence of NK cell receptors involved in the recognition of HLA-B and imply the presence of multiple receptors for MHC on an individual NK clone.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8046332-1328466,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8046332-1518825,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8046332-1541831,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8046332-1869832,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8046332-1975828,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8046332-2147946,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8046332-2664068,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8046332-2683611,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8046332-2707298,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8046332-2784569,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8046332-2785140,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8046332-3259252,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8046332-3877776,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8046332-3951539,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8046332-6086760,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8046332-6225799,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8046332-7140810,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8046332-8265660,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8046332-8376937,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8046332-8493555
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
180
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
537-43
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:8046332-Alleles,
pubmed-meshheading:8046332-Antibodies, Monoclonal,
pubmed-meshheading:8046332-B-Lymphocytes,
pubmed-meshheading:8046332-HLA-B Antigens,
pubmed-meshheading:8046332-Humans,
pubmed-meshheading:8046332-Killer Cells, Natural,
pubmed-meshheading:8046332-Polymorphism, Genetic,
pubmed-meshheading:8046332-Receptors, Immunologic,
pubmed-meshheading:8046332-Receptors, KIR,
pubmed-meshheading:8046332-Receptors, KIR3DL1,
pubmed-meshheading:8046332-Transfection
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pubmed:year |
1994
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pubmed:articleTitle |
NKB1: a natural killer cell receptor involved in the recognition of polymorphic HLA-B molecules.
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pubmed:affiliation |
Department of Human Immunology, DNAX Research Institute of Molecular and Cellular Biology, Inc., Palo Alto, California 94304.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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