| pubmed-article:8046328 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8046328 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
| pubmed-article:8046328 | lifeskim:mentions | umls-concept:C0021311 | lld:lifeskim |
| pubmed-article:8046328 | lifeskim:mentions | umls-concept:C1332717 | lld:lifeskim |
| pubmed-article:8046328 | lifeskim:mentions | umls-concept:C1706438 | lld:lifeskim |
| pubmed-article:8046328 | lifeskim:mentions | umls-concept:C0004561 | lld:lifeskim |
| pubmed-article:8046328 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:8046328 | lifeskim:mentions | umls-concept:C0085358 | lld:lifeskim |
| pubmed-article:8046328 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:8046328 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:8046328 | lifeskim:mentions | umls-concept:C1413244 | lld:lifeskim |
| pubmed-article:8046328 | lifeskim:mentions | umls-concept:C2698600 | lld:lifeskim |
| pubmed-article:8046328 | lifeskim:mentions | umls-concept:C0392756 | lld:lifeskim |
| pubmed-article:8046328 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:8046328 | pubmed:dateCreated | 1994-8-30 | lld:pubmed |
| pubmed-article:8046328 | pubmed:abstractText | We analyzed at clonal level the functional profile of circulating or skin-infiltrating T lymphocytes from two individuals infected with the human immunodeficiency virus type 1 (HIV-1), suffering from a Job's-like syndrome (eczematous dermatitis, recurrent skin and sinopulmonary infections, and hypergammaglobulinemia E) and showing virtually no circulating CD4+ T cells. Most of the CD3+ T cell clones generated from both patients were CD4- CD8+ TCR alpha beta +. The others were CD4- CD8- TCR alpha beta + which exhibited reduced mRNA expression for the CD8 molecule or no mRNA expression for either CD4 or CD8 molecules. The great majority of both CD4- CD8+ and CD4- CD8- did not produce interferon (IFN) gamma and exhibited reduced cytolytic activity. Rather, most of them produced large amounts of both interleukin (IL) 4 and IL-5 and provided B cell helper function for IgE synthesis. These data suggest that a switch of cytolytic CD8+ T cells showing a Th1-like cytokine secretion profile to cells that make Th2-type cytokines, exhibit reduced cytolytic potential, and provide B cell helper function can occur in the course of HIV-1 infection. These cells may contribute to the reduced defense against viral infections and intracellular parasites and account for the elevated IgE serum levels, eosinophilia, and the allergic-like clinical manifestations seen in a proportion of HIV-1-infected individuals. | lld:pubmed |
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| pubmed-article:8046328 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8046328 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8046328 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8046328 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8046328 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:8046328 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:8046328 | pubmed:author | pubmed-author:RomagnaniSS | lld:pubmed |
| pubmed-article:8046328 | pubmed:author | pubmed-author:MaggiEE | lld:pubmed |
| pubmed-article:8046328 | pubmed:author | pubmed-author:BiagiottiRR | lld:pubmed |
| pubmed-article:8046328 | pubmed:author | pubmed-author:AnnunziataPP | lld:pubmed |
| pubmed-article:8046328 | pubmed:author | pubmed-author:GiudiziM GMG | lld:pubmed |
| pubmed-article:8046328 | pubmed:author | pubmed-author:ZuccatiGG | lld:pubmed |
| pubmed-article:8046328 | pubmed:author | pubmed-author:ManettiRR | lld:pubmed |
| pubmed-article:8046328 | pubmed:author | pubmed-author:ParronchiPP | lld:pubmed |
| pubmed-article:8046328 | pubmed:author | pubmed-author:PiccinniM PMP | lld:pubmed |
| pubmed-article:8046328 | pubmed:author | pubmed-author:SampognaroSS | lld:pubmed |
| pubmed-article:8046328 | pubmed:author | pubmed-author:GiannariniLL | lld:pubmed |
| pubmed-article:8046328 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8046328 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:8046328 | pubmed:volume | 180 | lld:pubmed |
| pubmed-article:8046328 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8046328 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8046328 | pubmed:pagination | 489-95 | lld:pubmed |
| pubmed-article:8046328 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:8046328 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:8046328 | pubmed:articleTitle | Th2-like CD8+ T cells showing B cell helper function and reduced cytolytic activity in human immunodeficiency virus type 1 infection. | lld:pubmed |
| pubmed-article:8046328 | pubmed:affiliation | Division of Clinical Immunology and Allergy, University of Florence, Italy. | lld:pubmed |
| pubmed-article:8046328 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8046328 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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