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rdf:type |
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lifeskim:mentions |
umls-concept:C0004561,
umls-concept:C0019704,
umls-concept:C0021311,
umls-concept:C0039194,
umls-concept:C0085358,
umls-concept:C0392756,
umls-concept:C0441655,
umls-concept:C0542341,
umls-concept:C1332717,
umls-concept:C1413244,
umls-concept:C1706438,
umls-concept:C2698600
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pubmed:issue |
2
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pubmed:dateCreated |
1994-8-30
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pubmed:abstractText |
We analyzed at clonal level the functional profile of circulating or skin-infiltrating T lymphocytes from two individuals infected with the human immunodeficiency virus type 1 (HIV-1), suffering from a Job's-like syndrome (eczematous dermatitis, recurrent skin and sinopulmonary infections, and hypergammaglobulinemia E) and showing virtually no circulating CD4+ T cells. Most of the CD3+ T cell clones generated from both patients were CD4- CD8+ TCR alpha beta +. The others were CD4- CD8- TCR alpha beta + which exhibited reduced mRNA expression for the CD8 molecule or no mRNA expression for either CD4 or CD8 molecules. The great majority of both CD4- CD8+ and CD4- CD8- did not produce interferon (IFN) gamma and exhibited reduced cytolytic activity. Rather, most of them produced large amounts of both interleukin (IL) 4 and IL-5 and provided B cell helper function for IgE synthesis. These data suggest that a switch of cytolytic CD8+ T cells showing a Th1-like cytokine secretion profile to cells that make Th2-type cytokines, exhibit reduced cytolytic potential, and provide B cell helper function can occur in the course of HIV-1 infection. These cells may contribute to the reduced defense against viral infections and intracellular parasites and account for the elevated IgE serum levels, eosinophilia, and the allergic-like clinical manifestations seen in a proportion of HIV-1-infected individuals.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8046328-1328464,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8046328-1347305,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8046328-1401925,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8046328-1532000,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8046328-1681588,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8046328-1833502,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8046328-1968485,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8046328-2137843,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8046328-2147202,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8046328-2264889,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8046328-2303648,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8046328-2785902,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8046328-2965930,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8046328-4161105,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8046328-6600491,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8046328-7045227,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8046328-7905653,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8046328-7908324,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8046328-7909476,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8046328-8094248,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8046328-8096238,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8046328-8096699,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8046328-8097338,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8046328-8223881,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8046328-8386517,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8046328-8419468,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8046328-8421162,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8046328-8511588
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0022-1007
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pubmed:author |
pubmed-author:AnnunziataPP,
pubmed-author:BiagiottiRR,
pubmed-author:GiannariniLL,
pubmed-author:GiudiziM GMG,
pubmed-author:MaggiEE,
pubmed-author:ManettiRR,
pubmed-author:ParronchiPP,
pubmed-author:PiccinniM PMP,
pubmed-author:RomagnaniSS,
pubmed-author:SampognaroSS,
pubmed-author:ZuccatiGG
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
180
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
489-95
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:8046328-Antigens, CD4,
pubmed-meshheading:8046328-Antigens, CD8,
pubmed-meshheading:8046328-B-Lymphocytes,
pubmed-meshheading:8046328-Clone Cells,
pubmed-meshheading:8046328-Cytokines,
pubmed-meshheading:8046328-Cytotoxicity, Immunologic,
pubmed-meshheading:8046328-HIV Infections,
pubmed-meshheading:8046328-HIV-1,
pubmed-meshheading:8046328-Humans,
pubmed-meshheading:8046328-Interleukin-4,
pubmed-meshheading:8046328-Job's Syndrome,
pubmed-meshheading:8046328-Phenotype,
pubmed-meshheading:8046328-T-Lymphocytes, Helper-Inducer
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pubmed:year |
1994
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pubmed:articleTitle |
Th2-like CD8+ T cells showing B cell helper function and reduced cytolytic activity in human immunodeficiency virus type 1 infection.
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pubmed:affiliation |
Division of Clinical Immunology and Allergy, University of Florence, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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