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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1994-9-1
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pubmed:abstractText |
Arrestin is a component of the light transduction cascade that takes place in the outer segment of retinal rods. In situ hybridization and linkage analysis have localized the arrestin gene to a region of 50 cM between CRYG alpha and D2S23/D2S55 on chromosome 2q24-37. We have performed pairwise and multipoint linkage analysis between arrestin and four highly polymorphic markers from this region. The results indicate tight linkage between the gene and the microsatellite D2S172 (Zmax = 9.25 at theta = 0.038). This fine localization of the gene should provide a useful tool for cosegregation analyses involving the arrestin gene.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0340-6717
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
94
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
193-4
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:8045567-Antigens,
pubmed-meshheading:8045567-Arrestin,
pubmed-meshheading:8045567-Base Sequence,
pubmed-meshheading:8045567-Chromosome Mapping,
pubmed-meshheading:8045567-Eye Proteins,
pubmed-meshheading:8045567-Genetic Linkage,
pubmed-meshheading:8045567-Humans,
pubmed-meshheading:8045567-Lod Score,
pubmed-meshheading:8045567-Molecular Sequence Data,
pubmed-meshheading:8045567-Polymerase Chain Reaction,
pubmed-meshheading:8045567-Polymorphism, Genetic
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pubmed:year |
1994
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pubmed:articleTitle |
Genetic fine localization of the arrestin (S-antigen) gene 4 cM distal from D2S172.
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pubmed:affiliation |
Unitat de Genètica Molecular, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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