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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
|
| pubmed:dateCreated |
1978-12-2
|
| pubmed:abstractText |
The reaction scheme, developed for the synthesis of the gliotoxin analogue 2, was found to be of general applicability for analogues with varying substituents at N(1) and C(2). Analogues 11b-g prepared by this method are inhibitors of reverse transcriptase (RNA-directed DNA polymerase). Their inhibitory activity seems to be related to the lipophilicity of the effector molecules: the most lipophilic compound is the most active inhibitor. The techniques of reversed-phase thin-layer chromatography with silylated, precoated plates as well as reversed-phase high-performance liquid chromatography were used to measure the relative lipophilicities; both techniques gave analogous results.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0022-2623
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
21
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
796-9
|
| pubmed:dateRevised |
2005-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:80449-Anti-Bacterial Agents,
pubmed-meshheading:80449-Chromatography, Thin Layer,
pubmed-meshheading:80449-DNA-Directed DNA Polymerase,
pubmed-meshheading:80449-Gliotoxin,
pubmed-meshheading:80449-Kinetics,
pubmed-meshheading:80449-Lipid Metabolism,
pubmed-meshheading:80449-Moloney murine leukemia virus,
pubmed-meshheading:80449-Reverse Transcriptase Inhibitors
|
| pubmed:year |
1978
|
| pubmed:articleTitle |
Gliotoxin analogues as inhibitors of reverse transcriptase. 1. Effect of lipophilicity.
|
| pubmed:publicationType |
Journal Article
|