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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2 Pt 1
|
pubmed:dateCreated |
1994-8-19
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pubmed:abstractText |
A 36-year-old man had a high titer of antibody to Epstein-Barr virus (EBV) and recurrent necrotizing papules and nodules on his face and oral mucosa. The disease was diagnosed as CD3+4- 8+ large granular lymphocyte leukemia of T-cell origin. Southern blot analysis demonstrated that EBV DNA was present in CD8+ lymphocytes; EBV antigens were also observed in these lymphocytes. These findings demonstrated that EBV latently infected the leukemic cells and may have played a role in the pathogenesis of this disease. This is the first report of an association between EBV and large granular lymphocyte leukemia of T-cell origin.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Aug
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pubmed:issn |
0190-9622
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
31
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
251-5
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:8040410-Adult,
pubmed-meshheading:8040410-Blotting, Southern,
pubmed-meshheading:8040410-DNA, Viral,
pubmed-meshheading:8040410-Fluorescent Antibody Technique,
pubmed-meshheading:8040410-Herpesviridae Infections,
pubmed-meshheading:8040410-Herpesvirus 4, Human,
pubmed-meshheading:8040410-Humans,
pubmed-meshheading:8040410-Leukemia, T-Cell,
pubmed-meshheading:8040410-Leukemic Infiltration,
pubmed-meshheading:8040410-Male,
pubmed-meshheading:8040410-Skin,
pubmed-meshheading:8040410-Tumor Virus Infections
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pubmed:year |
1994
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pubmed:articleTitle |
Epstein-Barr virus-associated large granular lymphocyte leukemia with cutaneous infiltration.
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pubmed:affiliation |
Department of Dermatology, Osaka University School of Medicine, Suita, Japan.
|
pubmed:publicationType |
Journal Article,
Case Reports
|