| pubmed-article:8040328 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8040328 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:8040328 | lifeskim:mentions | umls-concept:C0014597 | lld:lifeskim |
| pubmed-article:8040328 | lifeskim:mentions | umls-concept:C0021760 | lld:lifeskim |
| pubmed-article:8040328 | lifeskim:mentions | umls-concept:C0085236 | lld:lifeskim |
| pubmed-article:8040328 | lifeskim:mentions | umls-concept:C1327616 | lld:lifeskim |
| pubmed-article:8040328 | lifeskim:mentions | umls-concept:C1514468 | lld:lifeskim |
| pubmed-article:8040328 | lifeskim:mentions | umls-concept:C1440080 | lld:lifeskim |
| pubmed-article:8040328 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:8040328 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:8040328 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:8040328 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:8040328 | pubmed:dateCreated | 1994-8-25 | lld:pubmed |
| pubmed-article:8040328 | pubmed:abstractText | The aims of this study were (a) to determine if rat alveolar type II (ATII) cells and human pulmonary epithelial-derived cells (A549 cell line) could generate IL-6 in vitro, (b) to characterize the cytokine regulation of IL-6 gene and protein expression in these cells, and (c) to detect the in vivo expression of immunoreactive IL-6 by human ATII cells. Rat ATII cells in primary culture secreted bioactive IL-6 and immunostained with an anti-IL-6 antiserum. Spontaneous IL-6 secretion by rat ATII cells amounted to 5,690 +/- 770 pg/ml/10(6) cells (n = 12) and was fivefold higher than spontaneous rat alveolar macrophages IL-6 secretion (1,052 +/- 286 pg/ml/10(6) cells, n = 8, P = 0.001). Rat alveolar macrophage conditioned media (CM) increased IL-6 secretion by rat ATII cells through the effect of IL-1 and TNF. IL-6 gene expression and IL-6 secretion by A549 cells was induced by IL-1 beta, TNF alpha, and by human alveolar macrophages and THP1 cells CM. Induction was abolished when CM were preincubated with anti-IL-1 beta and anti-TNF alpha antibody. The combination of IFN gamma and LPS induced the expression of IL-6 mRNA by A549 cells whereas LPS alone had no effect. Immunohistochemical staining evidenced the expression of immunoreactive IL-6 by hyperplastic ATII cells in fibrotic human lung, a condition in which alveolar macrophages are known to be activated. ATII cells in normal human lung did not express immunoreactive IL-6. Our findings demonstrate that ATII cells may be an important source of IL-6 in the alveolar space thereby participating to the regulation of the intra-alveolar immune response. | lld:pubmed |
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| pubmed-article:8040328 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8040328 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8040328 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:8040328 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8040328 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:8040328 | pubmed:issn | 0021-9738 | lld:pubmed |
| pubmed-article:8040328 | pubmed:author | pubmed-author:AubierMM | lld:pubmed |
| pubmed-article:8040328 | pubmed:author | pubmed-author:RollandCC | lld:pubmed |
| pubmed-article:8040328 | pubmed:author | pubmed-author:GuenounouMM | lld:pubmed |
| pubmed-article:8040328 | pubmed:author | pubmed-author:CrestaniBB | lld:pubmed |
| pubmed-article:8040328 | pubmed:author | pubmed-author:DehouxMM | lld:pubmed |
| pubmed-article:8040328 | pubmed:author | pubmed-author:CornilletPP | lld:pubmed |
| pubmed-article:8040328 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8040328 | pubmed:volume | 94 | lld:pubmed |
| pubmed-article:8040328 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8040328 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8040328 | pubmed:pagination | 731-40 | lld:pubmed |
| pubmed-article:8040328 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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