Linked Life Data

8039162

Source:http://linkedlifedata.com/resource/pubmed/id/8039162

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1994-8-25
pubmed:abstractText
Analysis of 20 primary prostatic tumors (local Gleason grades ranging from 1 to 4) was performed on archival material obtained from formalin-fixed, paraffin-embedded blocks. Alpha satellite probes specific for the pericentric regions of chromosomes 12, 17, X, and Y were used in fluorescence in situ hybridization (FISH) assays for the examination of aneusomies for these chromosomes. Eighty percent of specimens (16/20) showed significant loss of chromosome 17 and 55% (11/20 specimens) also showed significant loss of chromosome 12; all specimens that lost chromosome 12 lost chromosome 17. Gain of the X chromosome was observed in 40% (8/20) of specimens, all but one of which also showed loss of chromosome 17. While the specimens showing gain of the X chromosome may represent polyploid cells, only one specimen also showed significant gain of chromosomes 12 and 17, suggesting that both of these chromosomes may be lost in hyperdiploid prostate cancers. Loss of the Y chromosome was not statistically significant. This study thus indicates that loss of chromosome 17 is a frequent and likely early event in prostatic cancer.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0165-4608
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
75
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
40-4
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Evaluation of 20 archival prostate tumor specimens by fluorescence in situ hybridization (FISH).
pubmed:affiliation
Department of Human Genetics, University of Utah School of Medicine, Salt Lake City 84112.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't