rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1994-8-15
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pubmed:databankReference |
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pubmed:abstractText |
Cyclic ADP-ribose recently has been suggested to be an important intracellular signal for insulin secretion. CD38, which was originally isolated from human lymphocytes as a surface marker, is active in the synthesis of cyclic ADP-ribose. We report here the cloning of a rat CD38-homologous protein (CD38H) which is expressed in pancreatic islets. The deduced amino acid sequence shows that rat CD38H is a protein of 303 amino acids (M(r), 34.4 kD) and contains one possible membrane-spanning domain, consistent with a type II transmembrane glycoprotein. The overall identity and similarity of the amino acid sequences between the human CD38 and the rat CD38H are 58% and 76%, respectively. RNA blot analysis showed a strong signal of 3.4 kb in rat brain, duodenum, and heart. CD38H also is shown to be expressed in pancreatic islets by the RT-PCR procedure, but its expression is not significantly different in Wistar and GK rats, a genetic model of non-insulin-dependent diabetes mellitus. The presence of rat CD38H in the pancreatic islets suggests that CD38H may be involved in insulin secretion by synthesizing cADP-ribose.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/ADP-ribosyl Cyclase,
http://linkedlifedata.com/resource/pubmed/chemical/Adenosine Diphosphate Ribose,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD38,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation,
http://linkedlifedata.com/resource/pubmed/chemical/CD38 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Cd38 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic ADP-Ribose,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Primers,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0006-291X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
202
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
629-36
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8037769-ADP-ribosyl Cyclase,
pubmed-meshheading:8037769-Adenosine Diphosphate Ribose,
pubmed-meshheading:8037769-Amino Acid Sequence,
pubmed-meshheading:8037769-Animals,
pubmed-meshheading:8037769-Antigens, CD,
pubmed-meshheading:8037769-Antigens, CD38,
pubmed-meshheading:8037769-Antigens, Differentiation,
pubmed-meshheading:8037769-Aplysia,
pubmed-meshheading:8037769-Base Sequence,
pubmed-meshheading:8037769-Brain,
pubmed-meshheading:8037769-Cyclic ADP-Ribose,
pubmed-meshheading:8037769-DNA Primers,
pubmed-meshheading:8037769-Gene Expression,
pubmed-meshheading:8037769-Humans,
pubmed-meshheading:8037769-Islets of Langerhans,
pubmed-meshheading:8037769-Lymphocytes,
pubmed-meshheading:8037769-Male,
pubmed-meshheading:8037769-Membrane Glycoproteins,
pubmed-meshheading:8037769-Mice,
pubmed-meshheading:8037769-Molecular Sequence Data,
pubmed-meshheading:8037769-Polymerase Chain Reaction,
pubmed-meshheading:8037769-RNA, Messenger,
pubmed-meshheading:8037769-Rats,
pubmed-meshheading:8037769-Rats, Inbred Strains,
pubmed-meshheading:8037769-Rats, Wistar,
pubmed-meshheading:8037769-Sequence Homology, Amino Acid,
pubmed-meshheading:8037769-Species Specificity
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pubmed:year |
1994
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pubmed:articleTitle |
A cloned rat CD38-homologous protein and its expression in pancreatic islets.
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pubmed:affiliation |
Department of Metabolism and Clinical Nutrition, Kyoto University Faculty of Medicine, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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