Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1994-8-15
pubmed:databankReference
pubmed:abstractText
Cyclic ADP-ribose recently has been suggested to be an important intracellular signal for insulin secretion. CD38, which was originally isolated from human lymphocytes as a surface marker, is active in the synthesis of cyclic ADP-ribose. We report here the cloning of a rat CD38-homologous protein (CD38H) which is expressed in pancreatic islets. The deduced amino acid sequence shows that rat CD38H is a protein of 303 amino acids (M(r), 34.4 kD) and contains one possible membrane-spanning domain, consistent with a type II transmembrane glycoprotein. The overall identity and similarity of the amino acid sequences between the human CD38 and the rat CD38H are 58% and 76%, respectively. RNA blot analysis showed a strong signal of 3.4 kb in rat brain, duodenum, and heart. CD38H also is shown to be expressed in pancreatic islets by the RT-PCR procedure, but its expression is not significantly different in Wistar and GK rats, a genetic model of non-insulin-dependent diabetes mellitus. The presence of rat CD38H in the pancreatic islets suggests that CD38H may be involved in insulin secretion by synthesizing cADP-ribose.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0006-291X
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
202
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
629-36
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:8037769-ADP-ribosyl Cyclase, pubmed-meshheading:8037769-Adenosine Diphosphate Ribose, pubmed-meshheading:8037769-Amino Acid Sequence, pubmed-meshheading:8037769-Animals, pubmed-meshheading:8037769-Antigens, CD, pubmed-meshheading:8037769-Antigens, CD38, pubmed-meshheading:8037769-Antigens, Differentiation, pubmed-meshheading:8037769-Aplysia, pubmed-meshheading:8037769-Base Sequence, pubmed-meshheading:8037769-Brain, pubmed-meshheading:8037769-Cyclic ADP-Ribose, pubmed-meshheading:8037769-DNA Primers, pubmed-meshheading:8037769-Gene Expression, pubmed-meshheading:8037769-Humans, pubmed-meshheading:8037769-Islets of Langerhans, pubmed-meshheading:8037769-Lymphocytes, pubmed-meshheading:8037769-Male, pubmed-meshheading:8037769-Membrane Glycoproteins, pubmed-meshheading:8037769-Mice, pubmed-meshheading:8037769-Molecular Sequence Data, pubmed-meshheading:8037769-Polymerase Chain Reaction, pubmed-meshheading:8037769-RNA, Messenger, pubmed-meshheading:8037769-Rats, pubmed-meshheading:8037769-Rats, Inbred Strains, pubmed-meshheading:8037769-Rats, Wistar, pubmed-meshheading:8037769-Sequence Homology, Amino Acid, pubmed-meshheading:8037769-Species Specificity
pubmed:year
1994
pubmed:articleTitle
A cloned rat CD38-homologous protein and its expression in pancreatic islets.
pubmed:affiliation
Department of Metabolism and Clinical Nutrition, Kyoto University Faculty of Medicine, Japan.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't