| pubmed-article:8037735 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8037735 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
| pubmed-article:8037735 | lifeskim:mentions | umls-concept:C0085295 | lld:lifeskim |
| pubmed-article:8037735 | lifeskim:mentions | umls-concept:C0598312 | lld:lifeskim |
| pubmed-article:8037735 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:8037735 | lifeskim:mentions | umls-concept:C0961954 | lld:lifeskim |
| pubmed-article:8037735 | lifeskim:mentions | umls-concept:C1100939 | lld:lifeskim |
| pubmed-article:8037735 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:8037735 | pubmed:dateCreated | 1994-8-15 | lld:pubmed |
| pubmed-article:8037735 | pubmed:abstractText | Interleukin 10 (IL-10) is produced by TH2 lymphocytes and regulates both lymphoid and myeloid cells. In the present study we demonstrate that IL-10 is expressed and produced spontaneously in the peripheral blood mononuclear cells (PBMCs) of all HIV-1 infected individuals tested, 3 of 19 cases of HIV-negative lymphoma and none of five healthy controls. IL-10 mRNA was detectable in both monocytes/macrophages and T lymphocytes isolated from PBMCs of HIV infected patients. We have also shown that infection of promonocytic (U937) and T (H9) cell lines with HIV stimulates IL-10 secretion. Furthermore, a T cell line (H9) stably transfected with a HIV tat expression-vector secreted higher levels of IL-10. We have also demonstrated that rhIL-10 inhibited HIV-1 replication in infected monocytes and PBMCs in a dose dependent manner. IL-10 may thus participate in long latency between HIV-1 infection and development of AIDS. | lld:pubmed |
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| pubmed-article:8037735 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:8037735 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8037735 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8037735 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:8037735 | pubmed:issn | 0006-291X | lld:pubmed |
| pubmed-article:8037735 | pubmed:author | pubmed-author:LevineA MAM | lld:pubmed |
| pubmed-article:8037735 | pubmed:author | pubmed-author:GillP SPS | lld:pubmed |
| pubmed-article:8037735 | pubmed:author | pubmed-author:LawR ERE | lld:pubmed |
| pubmed-article:8037735 | pubmed:author | pubmed-author:PuriR KRK | lld:pubmed |
| pubmed-article:8037735 | pubmed:author | pubmed-author:HuangC LCL | lld:pubmed |
| pubmed-article:8037735 | pubmed:author | pubmed-author:ZhangYY | lld:pubmed |
| pubmed-article:8037735 | pubmed:author | pubmed-author:MoudgilTT | lld:pubmed |
| pubmed-article:8037735 | pubmed:author | pubmed-author:MasoodRR | lld:pubmed |
| pubmed-article:8037735 | pubmed:author | pubmed-author:Lunardi-Iskan... | lld:pubmed |
| pubmed-article:8037735 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8037735 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:8037735 | pubmed:volume | 202 | lld:pubmed |
| pubmed-article:8037735 | pubmed:geneSymbol | tat | lld:pubmed |
| pubmed-article:8037735 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8037735 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8037735 | pubmed:pagination | 374-83 | lld:pubmed |
| pubmed-article:8037735 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:8037735 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:8037735 | pubmed:articleTitle | IL-10 inhibits HIV-1 replication and is induced by tat. | lld:pubmed |
| pubmed-article:8037735 | pubmed:affiliation | Department of Medicine, University of Southern California, Los Angeles 90033. | lld:pubmed |
| pubmed-article:8037735 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8037735 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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