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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1994-8-15
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pubmed:abstractText |
Interleukin 10 (IL-10) is produced by TH2 lymphocytes and regulates both lymphoid and myeloid cells. In the present study we demonstrate that IL-10 is expressed and produced spontaneously in the peripheral blood mononuclear cells (PBMCs) of all HIV-1 infected individuals tested, 3 of 19 cases of HIV-negative lymphoma and none of five healthy controls. IL-10 mRNA was detectable in both monocytes/macrophages and T lymphocytes isolated from PBMCs of HIV infected patients. We have also shown that infection of promonocytic (U937) and T (H9) cell lines with HIV stimulates IL-10 secretion. Furthermore, a T cell line (H9) stably transfected with a HIV tat expression-vector secreted higher levels of IL-10. We have also demonstrated that rhIL-10 inhibited HIV-1 replication in infected monocytes and PBMCs in a dose dependent manner. IL-10 may thus participate in long latency between HIV-1 infection and development of AIDS.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0006-291X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
202
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pubmed:geneSymbol |
tat
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
374-83
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:8037735-Acquired Immunodeficiency Syndrome,
pubmed-meshheading:8037735-B-Lymphocytes,
pubmed-meshheading:8037735-Base Sequence,
pubmed-meshheading:8037735-Cell Line,
pubmed-meshheading:8037735-DNA Primers,
pubmed-meshheading:8037735-Gene Expression,
pubmed-meshheading:8037735-Gene Products, tat,
pubmed-meshheading:8037735-Genes, tat,
pubmed-meshheading:8037735-HIV Seronegativity,
pubmed-meshheading:8037735-HIV-1,
pubmed-meshheading:8037735-Humans,
pubmed-meshheading:8037735-Interleukin-10,
pubmed-meshheading:8037735-Lymphoma,
pubmed-meshheading:8037735-Macrophages,
pubmed-meshheading:8037735-Molecular Sequence Data,
pubmed-meshheading:8037735-Monocytes,
pubmed-meshheading:8037735-Polymerase Chain Reaction,
pubmed-meshheading:8037735-RNA, Messenger,
pubmed-meshheading:8037735-Reference Values,
pubmed-meshheading:8037735-T-Lymphocytes,
pubmed-meshheading:8037735-Transfection,
pubmed-meshheading:8037735-Virus Replication,
pubmed-meshheading:8037735-tat Gene Products, Human Immunodeficiency Virus
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pubmed:year |
1994
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pubmed:articleTitle |
IL-10 inhibits HIV-1 replication and is induced by tat.
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pubmed:affiliation |
Department of Medicine, University of Southern California, Los Angeles 90033.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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