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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1994-8-12
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pubmed:abstractText |
The effects of intracerebroventricular (i.c.v.) injection of histamine, the H1 agonist 2-methyl-histamine and the H2 agonist dimaprit were tested on carrageenin induced hyperalgesia by the Randall-Selitto paw pressure test in the rat. Treatment with histamine (0.1, 0.2, 0.4 mumol/rat, i.c.v.) 150 min after intraplantar carrageenin (0.1 ml of 1% solution) caused a significant increase of paw pressure thresholds in inflamed (but not in non-inflamed) paws. The magnitude and the duration of the antinociceptive effects of histamine were dose-dependent. Administration of 2-methyl-histamine (0.2, 0.4, 0.8, 1.0 mumol/rat, i.c.v.) and dimaprit (0.1, 0.2, 0.4, 0.8 mumol/rat, i.c.v.) also displayed dose-dependent blockade of carrageenin-induced hyperalgesia. Antinociceptive ED50 values calculated 30 min after drug treatments were: histamine 0.18 mumol/rat; 2-methyl-histamine 0.65 mumol/rat; dimaprit 0.33 mumol/rat. These data indicate that histamine through central H1 and H2 receptors exerts an inhibitory role in the control of nociception in pain resulting from inflammation.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/2-methylhistamine,
http://linkedlifedata.com/resource/pubmed/chemical/Carrageenan,
http://linkedlifedata.com/resource/pubmed/chemical/Dimaprit,
http://linkedlifedata.com/resource/pubmed/chemical/Histamine,
http://linkedlifedata.com/resource/pubmed/chemical/Histamine Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Methylhistamines
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0028-3908
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
33
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
205-10
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8035905-Animals,
pubmed-meshheading:8035905-Carrageenan,
pubmed-meshheading:8035905-Central Nervous System,
pubmed-meshheading:8035905-Dimaprit,
pubmed-meshheading:8035905-Histamine,
pubmed-meshheading:8035905-Histamine Agonists,
pubmed-meshheading:8035905-Hyperalgesia,
pubmed-meshheading:8035905-Male,
pubmed-meshheading:8035905-Methylhistamines,
pubmed-meshheading:8035905-Rats,
pubmed-meshheading:8035905-Rats, Sprague-Dawley
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pubmed:year |
1994
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pubmed:articleTitle |
Evidence for an inhibitory role of central histamine on carrageenin-induced hyperalgesia.
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pubmed:affiliation |
Department of Pharmacology, Chemotherapy and Medical Toxicology, University of Milan, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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