| pubmed-article:8035825 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8035825 | lifeskim:mentions | umls-concept:C0015576 | lld:lifeskim |
| pubmed-article:8035825 | lifeskim:mentions | umls-concept:C0027740 | lld:lifeskim |
| pubmed-article:8035825 | lifeskim:mentions | umls-concept:C0085262 | lld:lifeskim |
| pubmed-article:8035825 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:8035825 | lifeskim:mentions | umls-concept:C0018321 | lld:lifeskim |
| pubmed-article:8035825 | lifeskim:mentions | umls-concept:C0018270 | lld:lifeskim |
| pubmed-article:8035825 | lifeskim:mentions | umls-concept:C1451465 | lld:lifeskim |
| pubmed-article:8035825 | lifeskim:mentions | umls-concept:C1145667 | lld:lifeskim |
| pubmed-article:8035825 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:8035825 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:8035825 | pubmed:dateCreated | 1994-8-15 | lld:pubmed |
| pubmed-article:8035825 | pubmed:abstractText | It has been reported that growth factors activate Ras through a complex of an adaptor type SH2-containing molecule, Grb2, and a Ras guanine nucleotide-releasing protein (GNRP), mSos. We report on the involvement of another adaptor molecule, CRK, in the activation of Ras. Overexpression of wild-type CRK proteins CRK-I and CRK-II enhanced the nerve growth factor (NGF)-induced activation of Ras in PC12 cells, although the basal level of GTP-bound active Ras was not altered. In contrast, mutants with a single amino acid substitution in either the SH2 or SH3 domain of the CRK-I protein inhibited the NGF-induced activation of Ras. Two GNRPs for the Ras family, mSos and C3G, were coimmunoprecipitated with the endogenous Crk proteins in PC12 cells. The association between C3G and the CRK mutants was dependent upon the presence of intact SH3. The SH2 domain of CRK bound to the SHC protein phosphorylated on tyrosine residues by NGF stimulation. The results demonstrate that, in addition to Grb2, CRK participates in signaling from the NGF receptor and that two GNRPs appear to transmit signals from these adaptor molecules to Ras. | lld:pubmed |
| pubmed-article:8035825 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8035825 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8035825 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8035825 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8035825 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8035825 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8035825 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8035825 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8035825 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8035825 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8035825 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8035825 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8035825 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8035825 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8035825 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8035825 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8035825 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8035825 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8035825 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8035825 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8035825 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8035825 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8035825 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8035825 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8035825 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8035825 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8035825 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8035825 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8035825 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8035825 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8035825 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8035825 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8035825 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8035825 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8035825 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8035825 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8035825 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8035825 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8035825 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8035825 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8035825 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8035825 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8035825 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8035825 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8035825 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8035825 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8035825 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8035825 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8035825 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8035825 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8035825 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:8035825 | pubmed:issn | 0270-7306 | lld:pubmed |
| pubmed-article:8035825 | pubmed:author | pubmed-author:MatsudaMM | lld:pubmed |
| pubmed-article:8035825 | pubmed:author | pubmed-author:HashimotoYY | lld:pubmed |
| pubmed-article:8035825 | pubmed:author | pubmed-author:NakamuraSS | lld:pubmed |
| pubmed-article:8035825 | pubmed:author | pubmed-author:TanakaSS | lld:pubmed |
| pubmed-article:8035825 | pubmed:author | pubmed-author:HasegawaHH | lld:pubmed |
| pubmed-article:8035825 | pubmed:author | pubmed-author:KurataTT | lld:pubmed |
| pubmed-article:8035825 | pubmed:author | pubmed-author:HattoriSS | lld:pubmed |
| pubmed-article:8035825 | pubmed:author | pubmed-author:MuroyaKK | lld:pubmed |
| pubmed-article:8035825 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8035825 | pubmed:volume | 14 | lld:pubmed |
| pubmed-article:8035825 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8035825 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8035825 | pubmed:pagination | 5495-500 | lld:pubmed |
| pubmed-article:8035825 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:8035825 | pubmed:meshHeading | pubmed-meshheading:8035825-... | lld:pubmed |
| pubmed-article:8035825 | pubmed:meshHeading | pubmed-meshheading:8035825-... | lld:pubmed |
| pubmed-article:8035825 | pubmed:meshHeading | pubmed-meshheading:8035825-... | lld:pubmed |
| pubmed-article:8035825 | pubmed:meshHeading | pubmed-meshheading:8035825-... | lld:pubmed |
| pubmed-article:8035825 | pubmed:meshHeading | pubmed-meshheading:8035825-... | lld:pubmed |
| pubmed-article:8035825 | pubmed:meshHeading | pubmed-meshheading:8035825-... | lld:pubmed |
| pubmed-article:8035825 | pubmed:meshHeading | pubmed-meshheading:8035825-... | lld:pubmed |
| pubmed-article:8035825 | pubmed:meshHeading | pubmed-meshheading:8035825-... | lld:pubmed |
| pubmed-article:8035825 | pubmed:meshHeading | pubmed-meshheading:8035825-... | lld:pubmed |
| pubmed-article:8035825 | pubmed:meshHeading | pubmed-meshheading:8035825-... | lld:pubmed |
| pubmed-article:8035825 | pubmed:meshHeading | pubmed-meshheading:8035825-... | lld:pubmed |
| pubmed-article:8035825 | pubmed:meshHeading | pubmed-meshheading:8035825-... | lld:pubmed |
| pubmed-article:8035825 | pubmed:meshHeading | pubmed-meshheading:8035825-... | lld:pubmed |
| pubmed-article:8035825 | pubmed:meshHeading | pubmed-meshheading:8035825-... | lld:pubmed |
| pubmed-article:8035825 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:8035825 | pubmed:articleTitle | CRK protein binds to two guanine nucleotide-releasing proteins for the Ras family and modulates nerve growth factor-induced activation of Ras in PC12 cells. | lld:pubmed |
| pubmed-article:8035825 | pubmed:affiliation | Department of Pathology, National Institute of Health, Tokyo, Japan. | lld:pubmed |
| pubmed-article:8035825 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8035825 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:8035825 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:6464 | entrezgene:pubmed | pubmed-article:8035825 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:8035825 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8035825 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8035825 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8035825 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8035825 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8035825 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8035825 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8035825 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8035825 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8035825 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8035825 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8035825 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8035825 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8035825 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8035825 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8035825 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8035825 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8035825 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8035825 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8035825 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8035825 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8035825 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8035825 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8035825 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8035825 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8035825 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8035825 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8035825 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8035825 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8035825 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8035825 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8035825 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8035825 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8035825 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8035825 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8035825 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8035825 | lld:pubmed |
