Linked Life Data

8033969

Source:http://linkedlifedata.com/resource/pubmed/id/8033969

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1994-8-17
pubmed:abstractText
GABA depolarizes rat optic nerve axons and modulates axonal conduction through the activation of GABA-A receptors. To address whether an increase of [K+]e plays a major role in GABA actions on the rat optic nerve, we studied the effects of GABA on axonal conduction and [K+]e in the neonatal rat optic nerve in vitro. Double-barrelled K(+)-sensitive microelectrodes were used to record [K+]e. GABA (10(-4)-10(-3) M) increased [K+]e in the neonatal optic nerve. During prolonged application, the [K+]e slowly recovered. The increase in [K+]e induced by GABA was markedly reduced by the GABA-A receptor blocker bicuculline (10(-4) M). Isoguvacine (10(-4) M), a GABA-A agonist, mimicked the effect of GABA but produced larger responses at the same concentration. In contrast, baclofen (10(-4) M), a GABA-B agonist, had no effect on [K+]e. The changes in the compound action potential induced by GABA correlated only partially with the [K+]e changes. Furthermore, the changes in the compound action potential induced by elevation of K+ were far less than those induced by GABA. These results demonstrate that the GABA-evoked accumulation of [K+]e plays a secondary role in GABA actions on the neonatal rat optic nerve.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0014-4886
pubmed:author
pubmed:issnType
Print
pubmed:volume
127
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
291-7
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Effects of GABA on axonal conduction and extracellular potassium activity in the neonatal rat optic nerve.
pubmed:affiliation
Department of Neurosurgery, New York University Medical Center, New York 10016.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.