Linked Life Data

8033776

Source:http://linkedlifedata.com/resource/pubmed/id/8033776

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
1994-8-16
pubmed:abstractText
The activity of tryptophan hydroxylase was measured in the rat brainstem and cortex by the rate of in vivo accumulation of 5-hydroxytryptophan after inhibition of aromatic amino acid decarboxylase with 3-hydroxybenzyl-hydrazine. The activity of the enzyme was higher at mid-dark than mid-light in the two brain areas. Chronic administration of clomipramine increased the enzymatic activity at the two times of day to different levels of significance. In contrast, chronic mianserin led to a decrease but only to different levels of significance in the cortex. The significance of these results are discussed in relation to the theories implicating circadian rhythms in the mechanism of antidepressant action.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0012-835X
pubmed:author
pubmed:issnType
Print
pubmed:volume
70
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
721-4
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
The effects of chronic clomipramine and mianserin on the activity of tryptophan hydroxylase in the rat brain.
pubmed:affiliation
Department of Pharmacy, College of Health Sciences, University of Nairobi, Kenya.
pubmed:publicationType
Journal Article