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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
15
|
| pubmed:dateCreated |
1994-8-15
|
| pubmed:abstractText |
Genomic clones of nm23-H1 and -H2 were isolated. The nm23-H1 and -H2 genes were located in a tandem array 4 kilobases apart. Each genome contained 5 exons and most of the splicing sites in the exon-intron junctions of two isotypes were essentially identical. A probe derived from intron 4 of nm23-H1 was used to examine the loss of heterozygosity (LOH) in primary colorectal carcinomas. Twenty-nine of 42 samples were informative and LOH was found in 3 of these 29. In all three samples with LOH, cancer tissues expressed lower levels of nm23-H1 mRNA when compared with those without LOH.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0008-5472
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
54
|
| pubmed:geneSymbol |
nm23-H1,
nm23-H2
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
3979-82
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:8033126-Amino Acid Sequence,
pubmed-meshheading:8033126-Base Sequence,
pubmed-meshheading:8033126-Colorectal Neoplasms,
pubmed-meshheading:8033126-DNA, Neoplasm,
pubmed-meshheading:8033126-Exons,
pubmed-meshheading:8033126-Gene Deletion,
pubmed-meshheading:8033126-Genes, Tumor Suppressor,
pubmed-meshheading:8033126-Humans,
pubmed-meshheading:8033126-Introns,
pubmed-meshheading:8033126-Molecular Sequence Data,
pubmed-meshheading:8033126-Sequence Analysis, DNA
|
| pubmed:year |
1994
|
| pubmed:articleTitle |
Isolation of human nm23 genomes and analysis of loss of heterozygosity in primary colorectal carcinomas using a specific genomic probe.
|
| pubmed:affiliation |
Department of Oncology, Nagasaki University School of Medicine, Japan.
|
| pubmed:publicationType |
Journal Article
|