Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1994-8-16
pubmed:abstractText
1. Currently available antagonists and agonists cannot distinguish between angiotensin AT1 receptor subtypes. 2. We synthesized a series of compounds selected on the basis of having the most diverse structural features with respect to losartan (DuP753), the prototype non-peptide AT1 receptor antagonist. Using a radioligand-receptor binding assay and membranes prepared from COS-M6 cells transfected with individual AT1 receptor subtypes, we determined whether any of these compounds could distinguish between the receptor subtypes. 3. The diversity of the structural features of this series of compounds was reflected by the wide range of affinities (pIC50 values) displayed towards competing with [125I]-Sar1Ile8 angiotensin II for binding to the AT1 receptors. 4. Direct comparisons of the pIC50 values of individual compounds for rat AT1A, AT1B and human AT1 receptors revealed only minor differences. 5. It is concluded that compounds based structurally on losartan are unlikely to distinguish between these receptors.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/8032651-1436092, http://linkedlifedata.com/resource/pubmed/commentcorrection/8032651-1467838, http://linkedlifedata.com/resource/pubmed/commentcorrection/8032651-14907713, http://linkedlifedata.com/resource/pubmed/commentcorrection/8032651-1543512, http://linkedlifedata.com/resource/pubmed/commentcorrection/8032651-1544458, http://linkedlifedata.com/resource/pubmed/commentcorrection/8032651-1550596, http://linkedlifedata.com/resource/pubmed/commentcorrection/8032651-1567388, http://linkedlifedata.com/resource/pubmed/commentcorrection/8032651-1575451, http://linkedlifedata.com/resource/pubmed/commentcorrection/8032651-191856, http://linkedlifedata.com/resource/pubmed/commentcorrection/8032651-2017158, http://linkedlifedata.com/resource/pubmed/commentcorrection/8032651-2022414, http://linkedlifedata.com/resource/pubmed/commentcorrection/8032651-2024289, http://linkedlifedata.com/resource/pubmed/commentcorrection/8032651-2041569, http://linkedlifedata.com/resource/pubmed/commentcorrection/8032651-2041570, http://linkedlifedata.com/resource/pubmed/commentcorrection/8032651-2043107, http://linkedlifedata.com/resource/pubmed/commentcorrection/8032651-2043116, http://linkedlifedata.com/resource/pubmed/commentcorrection/8032651-2590220, http://linkedlifedata.com/resource/pubmed/commentcorrection/8032651-2775266, http://linkedlifedata.com/resource/pubmed/commentcorrection/8032651-7683830
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0007-1188
pubmed:author
pubmed:issnType
Print
pubmed:volume
112
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
277-81
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed-meshheading:8032651-Angiotensin I, pubmed-meshheading:8032651-Angiotensin Receptor Antagonists, pubmed-meshheading:8032651-Animals, pubmed-meshheading:8032651-Binding, Competitive, pubmed-meshheading:8032651-Biphenyl Compounds, pubmed-meshheading:8032651-Cell Line, pubmed-meshheading:8032651-DNA, Complementary, pubmed-meshheading:8032651-Humans, pubmed-meshheading:8032651-Imidazoles, pubmed-meshheading:8032651-Losartan, pubmed-meshheading:8032651-Membranes, pubmed-meshheading:8032651-Plasmids, pubmed-meshheading:8032651-Polymerase Chain Reaction, pubmed-meshheading:8032651-Radioligand Assay, pubmed-meshheading:8032651-Rats, pubmed-meshheading:8032651-Receptors, Angiotensin, pubmed-meshheading:8032651-Recombinant Proteins, pubmed-meshheading:8032651-Tetrazoles, pubmed-meshheading:8032651-Transfection
pubmed:year
1994
pubmed:articleTitle
Comparative pharmacology of recombinant rat AT1A, AT1B and human AT1 receptors expressed by transfected COS-M6 cells.
pubmed:affiliation
Department of Cardiovascular Studies, University of Leeds, Middlesex.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't