Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4 Pt 1
|
pubmed:dateCreated |
1994-8-12
|
pubmed:abstractText |
The hemodynamic and humoral effects of the specific human renin inhibitor R-PEP-27 were studied in six normal human subjects on low and high sodium intake diets. An intravenous infusion of R-PEP-27 (0.5 to 16 micrograms/min/kg body wt) reduced blood pressure in a dose-dependent fashion; the mean arterial blood pressure at the end of the infusion fell from 128 +/- 4/83 +/- 4 to 119 +/- 3/71 +/- 3 mm Hg (mean +/- SEM) (P < .01) during the low sodium intake diet. R-PEP-27 had no effect on blood pressure during the high sodium intake diet. R-PEP-27 significantly reduced plasma angiotensin II and aldosterone concentrations. The temporal response to R-PEP-27 suggests that it is a short-lived although highly potent competitive inhibitor of renin; this peptide is a valuable and specific physiologic probe of the renin-angiotensin system.
|
pubmed:grant | |
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Aldosterone,
http://linkedlifedata.com/resource/pubmed/chemical/Angiotensin II,
http://linkedlifedata.com/resource/pubmed/chemical/Oligopeptides,
http://linkedlifedata.com/resource/pubmed/chemical/Renin,
http://linkedlifedata.com/resource/pubmed/chemical/renin inhibitory peptide, R-PEP-27
|
pubmed:status |
MEDLINE
|
pubmed:month |
Apr
|
pubmed:issn |
0895-7061
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
7
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
295-301
|
pubmed:dateRevised |
2009-2-24
|
pubmed:meshHeading |
pubmed-meshheading:8031544-Adult,
pubmed-meshheading:8031544-Aldosterone,
pubmed-meshheading:8031544-Angiotensin II,
pubmed-meshheading:8031544-Blood Pressure,
pubmed-meshheading:8031544-Female,
pubmed-meshheading:8031544-Homeostasis,
pubmed-meshheading:8031544-Humans,
pubmed-meshheading:8031544-Male,
pubmed-meshheading:8031544-Middle Aged,
pubmed-meshheading:8031544-Oligopeptides,
pubmed-meshheading:8031544-Osmolar Concentration,
pubmed-meshheading:8031544-Reference Values,
pubmed-meshheading:8031544-Renin,
pubmed-meshheading:8031544-Urine
|
pubmed:year |
1994
|
pubmed:articleTitle |
R-PEP-27, a potent renin inhibitor, decreases plasma angiotensin II and blood pressure in normal volunteers.
|
pubmed:affiliation |
Division of Hypertension and Vascular Medicine, Massachusetts General Hospital, Boston 02114.
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
|