Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:dateCreated |
1994-8-9
|
pubmed:abstractText |
Human milk was found to become antiviral during storage at 4 degrees C because of the release of fatty acids by lipolysis. The stored milk caused more than a 10,000-fold inactivation of visna virus during incubation at 37 degrees C for 30 minutes. Medium-chain saturated and long-chain unsaturated fatty acids inactivated visna virus and other enveloped viruses causing more than a 3000-fold to 10,000-fold reduction in virus titer. 1-Monoglycerides and ethers of medium-chain fatty acids were more antiviral than the corresponding free fatty acids. Antiviral fatty acids were found to affect the viral envelope, causing leakage and, at higher concentrations, a complete disintegration of the envelope and the viral particles. Lipids commonly found in natural products could possibly be used as antiviral agents against enveloped viruses.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antiviral Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Ethers,
http://linkedlifedata.com/resource/pubmed/chemical/Fatty Acids, Nonesterified,
http://linkedlifedata.com/resource/pubmed/chemical/Glycerides,
http://linkedlifedata.com/resource/pubmed/chemical/Viral Envelope Proteins
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jun
|
pubmed:issn |
0077-8923
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:day |
6
|
pubmed:volume |
724
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
465-71
|
pubmed:dateRevised |
2003-11-14
|
pubmed:meshHeading |
pubmed-meshheading:8030974-Animals,
pubmed-meshheading:8030974-Antiviral Agents,
pubmed-meshheading:8030974-Cells, Cultured,
pubmed-meshheading:8030974-Ethers,
pubmed-meshheading:8030974-Fatty Acids, Nonesterified,
pubmed-meshheading:8030974-Glycerides,
pubmed-meshheading:8030974-Hydrolysis,
pubmed-meshheading:8030974-Milk, Human,
pubmed-meshheading:8030974-Sheep,
pubmed-meshheading:8030974-Viral Envelope Proteins,
pubmed-meshheading:8030974-Visna-maedi virus
|
pubmed:year |
1994
|
pubmed:articleTitle |
Inactivation of visna virus and other enveloped viruses by free fatty acids and monoglycerides.
|
pubmed:affiliation |
Institute of Biology, University of Iceland, Grensavegi, Reykjavík.
|
pubmed:publicationType |
Journal Article
|