Linked Life Data

8028586

Source:http://linkedlifedata.com/resource/pubmed/id/8028586

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1994-8-8
pubmed:databankReference
pubmed:abstractText
One of the most prevalent genetic lineages of group A streptococci (GAS) harbors a genomic locus termed the large vir regulon, which contains an emm gene encoding the antiphagocytic M protein, and structurally related fcrA and enn (emm-related) genes encoding immunoglobulin-binding proteins. In the present study more than 100 large vir regulons from 42 different GAS serotypes were analyzed by PCR and partial DNA sequencing. On comparing these data to published sequences, sites of mutational and putative recombinational events were identified and ordered with respect to their intra/intergenic or intra/intergenomic nature. The emm-related genes were found to display small intragenic deletions or insertions, were completely deleted from, or newly inserted into the genome, or were fused to adjacent genes. Intergenomic exchanges of complete emm-related genes, or segments thereof, between different vir regulons were detected. Most of these processes seem to involve short flanking direct repeats. Occasionally, the structural changes could be correlated with changes in the functions of the encoded proteins.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0026-8925
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
243
pubmed:geneSymbol
emm, fcrA
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
691-8
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:8028586-Amino Acid Sequence, pubmed-meshheading:8028586-Antigens, Bacterial, pubmed-meshheading:8028586-Bacterial Outer Membrane Proteins, pubmed-meshheading:8028586-Bacterial Proteins, pubmed-meshheading:8028586-Base Sequence, pubmed-meshheading:8028586-Carrier Proteins, pubmed-meshheading:8028586-Genes, Bacterial, pubmed-meshheading:8028586-Genetic Variation, pubmed-meshheading:8028586-Molecular Sequence Data, pubmed-meshheading:8028586-Mutagenesis, Insertional, pubmed-meshheading:8028586-Recombination, Genetic, pubmed-meshheading:8028586-Regulon, pubmed-meshheading:8028586-Sequence Deletion, pubmed-meshheading:8028586-Sequence Homology, Nucleic Acid, pubmed-meshheading:8028586-Serotyping, pubmed-meshheading:8028586-Streptococcus pyogenes, pubmed-meshheading:8028586-Virulence
pubmed:year
1994
pubmed:articleTitle
Genetic variability of the emm-related gene of the large vir regulon of group A streptococci: potential intra- and intergenomic recombination events.
pubmed:affiliation
Institute of Medical Microbiology, Technical University (RWTH), Aachen, Germany.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't