Linked Life Data

8027513

Source:http://linkedlifedata.com/resource/pubmed/id/8027513

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1994-8-5
pubmed:abstractText
The effects of butoxyacetic acid (BAA), a metabolite of the important solvent 2-butoxyethanol, on rat and human red blood cells (RBCs) were investigated. Rat RBCs demonstrated decreased deformability as assessed by a sensitive polycarbonate sieve filtration technique and an increased mean cellular volume after incubation with 0.2 and 2.0 mM BAA for 1-4 h. Evaluation of erythrocyte morphology showed that rat RBCs exposed to BAA became spherocytic and lysed to form erythrocyte membrane ghosts. Hemolysis of rat erythrocytes was rapid in 2.0 mM BAA. Changes in the deformability of rat erythrocytes appear to precede hemolysis. Treated rat erythrocytes also demonstrated a tendency to agglutinate and to release hemoglobin, which formed visible precipitates. None of the adverse effects seen in the RBCs of rats were observed in human blood similarly incubated with 2.0 mM BAA.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0260-437X
pubmed:author
pubmed:issnType
Print
pubmed:volume
14
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
91-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
Hemolysis and deformability of erythrocytes exposed to butoxyacetic acid, a metabolite of 2-butoxyethanol: I. Sensitivity in rats and resistance in normal humans.
pubmed:affiliation
Department of Medicine, Baylor College of Medicine, Houston, TX 77030.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't