Linked Life Data

8027280

Source:http://linkedlifedata.com/resource/pubmed/id/8027280

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1994-8-9
pubmed:abstractText
Elevated plasma follicle stimulating hormone (FSH) during the reproductive life is an early manifestation of ovarian ageing. The presence of elevated basal FSH in young, regularly menstruating women may represent a stage of menopausal transition consequent on premature ovarian failure. A total of 48 regularly menstruating, infertile women aged < 40 years, with high FSH and aged-matched controls with normal FSH underwent detailed monitoring of endocrine and follicle growth during one complete menstrual cycle. During the same cycle, detailed immunological screening was performed and the epidemiological features of all subjects were also reviewed. Subjects in the high FSH group had significantly higher basal FSH, luteinizing hormone (LH) and follicular phase LH concentrations. Despite their normal preovulatory oestradiol production, the high FSH group showed significantly slower follicular growth, smaller follicle diameter and lower luteal phase salivary progesterone. All these features have been described in older women during their menopausal transition. In addition, the prevalence of autoimmune antibodies was significantly higher in the high FSH group. This study suggests that infertile women with elevated FSH are in their perimenopause despite having regular ovulatory and apparently normal cycles. An autoimmune basis is suggested as a factor underlying their premature ovarian failure. Further endocrinological and autoimmunological follow-up is recommended.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0268-1161
pubmed:author
pubmed:issnType
Print
pubmed:volume
9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
245-52
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
The significance of elevated basal follicle stimulating hormone in regularly menstruating infertile women.
pubmed:affiliation
University Department of Obstetrics and Gynaecology, Jessop Hospital for Women, Sheffield, UK.
pubmed:publicationType
Journal Article, Clinical Trial, Randomized Controlled Trial, Research Support, Non-U.S. Gov't