Linked Life Data

802632

Source:http://linkedlifedata.com/resource/pubmed/id/802632

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1978-12-2
pubmed:abstractText
1. Prazosin had a considerable anti-hypertensive effect in both lying and standing posture in a mixed group of twenty-four patients in an open clinical trial. The drug was well tolerated and side-effects were few. 2. Tested on rat blood vessels, prazosin was ten times more potent on a molar basis than phentolamine in blocking the vasoconstrictor effects of noradrenaline. In the absence of vasoconstrictor nervous activity, no vasodilatation was observed. 3. In genetically hypertensive rats, prazosin in large doses caused a substantial fall in blood pressure, total exchangeable sodium and extracellular fluid volume. Tolerance to these effects started to develop within 20 days. In normotensive rats, blood pressure was lowered but total exchangeable sodium and extracellular fluid volume were not affected.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0144-4107
pubmed:author
pubmed:issnType
Print
pubmed:volume
2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
177s-179s
pubmed:dateRevised
2008-2-12
pubmed:meshHeading
pubmed:year
1975
pubmed:articleTitle
Prazosin: preliminary clinical and pharmacological observations.
pubmed:publicationType
Journal Article, Clinical Trial