Linked Life Data

8024641

Source:http://linkedlifedata.com/resource/pubmed/id/8024641

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1994-8-1
pubmed:abstractText
This paper reports data indicating that, in the rat, sodium monofluorophosphate (MFP, CAS 10163-15-2) is absorbed without hydrolysis through the stomach. This phenomenon and the fact that MFP binds to plasma globulins produce a prompt increase in protein-bound MFP concentration, significantly greater than the increase in plasma ultrafilterable fluoride. Intestinal absorption of MFP was investigated with the isolated duodenal loop in situ. The drug was hydrolyzed to fluoride at the intestinal lumen with a rate of approx. 3 times greater than that for fluoride absorption. After filling the duodenal loop with a MFP solution, ultrafiltrable fluoride accounts for the increase in plasma fluoride concentration, with no evidence of protein-bound MFP. This report also includes analytical techniques for the measurement of MFP in test solutions and in plasma.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0004-4172
pubmed:author
pubmed:issnType
Print
pubmed:volume
44
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
651-5
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Gastric and intestinal absorption of monofluorophosphate and fluoride in the rat.
pubmed:affiliation
Laboratorio de Biologia Osea, Facultad de Medicina, Rosario, Argentina.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't