Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions |
umls-concept:C0000726,
umls-concept:C0002766,
umls-concept:C0006400,
umls-concept:C0026549,
umls-concept:C0032790,
umls-concept:C0040808,
umls-concept:C0205146,
umls-concept:C0205195,
umls-concept:C0332448,
umls-concept:C0445204,
umls-concept:C0543467,
umls-concept:C0592511,
umls-concept:C1282910,
umls-concept:C2349975
|
| pubmed:issue |
3
|
| pubmed:dateCreated |
1994-8-4
|
| pubmed:abstractText |
In a randomized, blinded trial we assessed the value of adding preoperative infiltration of the surgical area with bupivacaine to a low dose epidural regimen for postoperative pain treatment. Forty-nine patients scheduled for major upper abdominal surgery during combined thoracic epidural (bupivacaine + morphine) and general anaesthesia were studied. Postoperative analgesia was epidural bupivacaine 10 mg/hr-1 + morphine 0.2 mg/hr-1 for 72 h. The patients randomly received preoperative infiltration of the surgical area with bupivacaine 0.25%, 40 ml (group I); or no infiltration (group II). Pain was evaluated at rest, during cough and during mobilization six and eight h after start of surgery, and at 8 a.m. and 4 p.m. on the following days until 72 h after start of surgery. The sensory level of analgesia was evaluated by pin prick. We found no difference between the two groups during rest and cough. However, during mobilization group I had lower pain scores compared to group II (P < 0.05). There was a significant reduction in the need for supplemental intramuscular morphine in the treatment group compared to the control group (P < 0.05). Thus an enhanced analgesic effect was demonstrated by adding preoperative infiltration of the surgical area with local anaesthetic to a low dose epidural bupivacaine/morphine regimen after upper abdominal surgery.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0001-5172
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
38
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
262-5
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:8023667-Abdomen,
pubmed-meshheading:8023667-Adult,
pubmed-meshheading:8023667-Aged,
pubmed-meshheading:8023667-Analgesia,
pubmed-meshheading:8023667-Analgesia, Epidural,
pubmed-meshheading:8023667-Bupivacaine,
pubmed-meshheading:8023667-Cough,
pubmed-meshheading:8023667-Double-Blind Method,
pubmed-meshheading:8023667-Drug Combinations,
pubmed-meshheading:8023667-Humans,
pubmed-meshheading:8023667-Injections, Intramuscular,
pubmed-meshheading:8023667-Injections, Subcutaneous,
pubmed-meshheading:8023667-Middle Aged,
pubmed-meshheading:8023667-Morphine,
pubmed-meshheading:8023667-Movement,
pubmed-meshheading:8023667-Pain, Postoperative,
pubmed-meshheading:8023667-Pain Measurement,
pubmed-meshheading:8023667-Posture,
pubmed-meshheading:8023667-Preoperative Care,
pubmed-meshheading:8023667-Skin
|
| pubmed:year |
1994
|
| pubmed:articleTitle |
Preoperative infiltration of the surgical area enhances postoperative analgesia of a combined low-dose epidural bupivacaine and morphine regimen after upper abdominal surgery.
|
| pubmed:affiliation |
Department of Anaesthesiology, Herlev Hospital, University of Copenhagen, Denmark.
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial
|