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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
7
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pubmed:dateCreated |
1994-7-29
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pubmed:abstractText |
Activated leukocytes appear to potentiate central nervous system reperfusion injury, and agents that block leukocyte adhesion have shown neuroprotective efficacy in experimental models. Doxycycline, a tetracycline antibiotic, inhibits leukocyte function in vitro, presumably through divalent cation binding. We used a model of focal central nervous system reperfusion injury to determine the efficacy of doxycycline treatment in preserving neurological function.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0039-2499
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
25
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1411-5; discussion 1416
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:8023357-Animals,
pubmed-meshheading:8023357-Cell Adhesion,
pubmed-meshheading:8023357-Doxycycline,
pubmed-meshheading:8023357-Ischemia,
pubmed-meshheading:8023357-Leukocytes,
pubmed-meshheading:8023357-Male,
pubmed-meshheading:8023357-Neutrophils,
pubmed-meshheading:8023357-Rabbits,
pubmed-meshheading:8023357-Reperfusion Injury,
pubmed-meshheading:8023357-Spinal Cord
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pubmed:year |
1994
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pubmed:articleTitle |
Reduction of central nervous system reperfusion injury in rabbits using doxycycline treatment.
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pubmed:affiliation |
Department of Neurology, Oregon Health Sciences University, Portland 97201.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|