Linked Life Data

8023023

Source:http://linkedlifedata.com/resource/pubmed/id/8023023

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1994-8-2
pubmed:abstractText
Multiple functions have been ascribed to the pontile pneumotaxic center. We hypothesized that these functions might be separable among neurons in different regions. In decerebrate, vagotomized, paralyzed and ventilated cats, activities of the phrenic and triangularis sterni nerves were recorded. Microinjections of kainic acid were used to destroy neurons. Neurons in the rostrolateral tegmentum at the ponto-mesencephalic border controlled the duration of neural inspiration. Expiratory duration was controlled by neurons in the more caudal nucleus parabrachialis medialis and Kolliker-Fuse nucleus. Ventilatory responses to hypercapnia were depressed following injections of kainic acid into regions controlling either inspiratory or expiratory durations. The phases of expiration were regulated by two groups of neurons, located medial and lateral in the rostral pons. We conclude that rostral pontile and mesencephalic mechanisms control multiple aspects of the eupneic ventilatory cycle. There mechanisms are served by neurons in separable anatomical regions.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0034-5687
pubmed:author
pubmed:issnType
Print
pubmed:volume
96
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
83-98
pubmed:dateRevised
2009-11-11
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Separation of multiple functions in ventilatory control of pneumotaxic mechanisms.
pubmed:affiliation
Department of Physiology, Dartmouth Medical School, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03755.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.