Linked Life Data

8022856

Source:http://linkedlifedata.com/resource/pubmed/id/8022856

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1994-8-4
pubmed:abstractText
The emerging understanding of the structural basis of biological function has made possible a new technology of rational drug design. This technology uses a combination of modeling and intensive computational tools, but also relies critically on direct structural methods for verification and to provide direction for new leads. The present work illustrates applications of this technology to ligand design for several model systems, including iterative modeling and crystallographic design of streptavidin ligands, ranking of streptavidin ligands using comparative molecular field analysis and ranking of thermolysin inhibitors using Poisson-Boltzman methods.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0163-7258
pubmed:author
pubmed:issnType
Print
pubmed:volume
60
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
169-83
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Biophysical tools for structure-based drug design.
pubmed:affiliation
Sterling Winthrop Inc., Collegeville, PA 19426.
pubmed:publicationType
Journal Article, Review