Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
14
pubmed:dateCreated
1994-8-1
pubmed:abstractText
Nascent mRNA chains are capped at the 5' end by the addition of a guanylyl residue to form a G(5')ppp(5')N ... structure. During the capping reaction, the guanylyltransferase (GTP:mRNA guanylyltransferase, EC 2.7.7.50) is reversibly and covalently guanylylated. In this enzyme-GMP (E-GMP) intermediate, GMP is linked to the epsilon-amino group of a lysine residue via a phosphoamide bond. Lys-70 was identified as the GMP attachment site of the Saccharomyces cerevisiae guanylyltransferase (encoded by the CEG1 gene) by guanylylpeptide sequencing. CEG1 genes with substitutions at Lys-70 were unable to support viability in yeast and produced proteins that were not guanylylated in vitro. The CEG1 active site exhibits sequence similarity to the active sites of viral guanylyltransferases and polynucleotide ligases, suggesting similarity in the mechanisms of nucleotidyl transfer catalyzed by these enzymes.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/8022828-1315757, http://linkedlifedata.com/resource/pubmed/commentcorrection/8022828-1322600, http://linkedlifedata.com/resource/pubmed/commentcorrection/8022828-1437556, http://linkedlifedata.com/resource/pubmed/commentcorrection/8022828-1497311, http://linkedlifedata.com/resource/pubmed/commentcorrection/8022828-1526462, http://linkedlifedata.com/resource/pubmed/commentcorrection/8022828-1546295, http://linkedlifedata.com/resource/pubmed/commentcorrection/8022828-1561104, http://linkedlifedata.com/resource/pubmed/commentcorrection/8022828-1614852, http://linkedlifedata.com/resource/pubmed/commentcorrection/8022828-1649507, http://linkedlifedata.com/resource/pubmed/commentcorrection/8022828-1656591, http://linkedlifedata.com/resource/pubmed/commentcorrection/8022828-1704411, http://linkedlifedata.com/resource/pubmed/commentcorrection/8022828-1840584, http://linkedlifedata.com/resource/pubmed/commentcorrection/8022828-1956768, http://linkedlifedata.com/resource/pubmed/commentcorrection/8022828-1988940, http://linkedlifedata.com/resource/pubmed/commentcorrection/8022828-2005781, http://linkedlifedata.com/resource/pubmed/commentcorrection/8022828-2159008, http://linkedlifedata.com/resource/pubmed/commentcorrection/8022828-2166212, http://linkedlifedata.com/resource/pubmed/commentcorrection/8022828-2166684, http://linkedlifedata.com/resource/pubmed/commentcorrection/8022828-2204063, http://linkedlifedata.com/resource/pubmed/commentcorrection/8022828-2207062, http://linkedlifedata.com/resource/pubmed/commentcorrection/8022828-2555782, http://linkedlifedata.com/resource/pubmed/commentcorrection/8022828-2659436, http://linkedlifedata.com/resource/pubmed/commentcorrection/8022828-2693907, http://linkedlifedata.com/resource/pubmed/commentcorrection/8022828-2824487, http://linkedlifedata.com/resource/pubmed/commentcorrection/8022828-291913, http://linkedlifedata.com/resource/pubmed/commentcorrection/8022828-3018296, http://linkedlifedata.com/resource/pubmed/commentcorrection/8022828-3018436, http://linkedlifedata.com/resource/pubmed/commentcorrection/8022828-3029058, http://linkedlifedata.com/resource/pubmed/commentcorrection/8022828-3036206, http://linkedlifedata.com/resource/pubmed/commentcorrection/8022828-3156376, http://linkedlifedata.com/resource/pubmed/commentcorrection/8022828-3277966, http://linkedlifedata.com/resource/pubmed/commentcorrection/8022828-3326038, http://linkedlifedata.com/resource/pubmed/commentcorrection/8022828-3402337, http://linkedlifedata.com/resource/pubmed/commentcorrection/8022828-3549293, http://linkedlifedata.com/resource/pubmed/commentcorrection/8022828-3586029, http://linkedlifedata.com/resource/pubmed/commentcorrection/8022828-3739227, http://linkedlifedata.com/resource/pubmed/commentcorrection/8022828-3882425, http://linkedlifedata.com/resource/pubmed/commentcorrection/8022828-3909103, http://linkedlifedata.com/resource/pubmed/commentcorrection/8022828-4910303, http://linkedlifedata.com/resource/pubmed/commentcorrection/8022828-6092377, http://linkedlifedata.com/resource/pubmed/commentcorrection/8022828-6264433, http://linkedlifedata.com/resource/pubmed/commentcorrection/8022828-6281766, http://linkedlifedata.com/resource/pubmed/commentcorrection/8022828-6281779, http://linkedlifedata.com/resource/pubmed/commentcorrection/8022828-6282835, http://linkedlifedata.com/resource/pubmed/commentcorrection/8022828-6314278, http://linkedlifedata.com/resource/pubmed/commentcorrection/8022828-6321153, http://linkedlifedata.com/resource/pubmed/commentcorrection/8022828-6324112, http://linkedlifedata.com/resource/pubmed/commentcorrection/8022828-6370680, http://linkedlifedata.com/resource/pubmed/commentcorrection/8022828-7275966, http://linkedlifedata.com/resource/pubmed/commentcorrection/8022828-7310871, http://linkedlifedata.com/resource/pubmed/commentcorrection/8022828-8227060, http://linkedlifedata.com/resource/pubmed/commentcorrection/8022828-8367444, http://linkedlifedata.com/resource/pubmed/commentcorrection/8022828-8382399, http://linkedlifedata.com/resource/pubmed/commentcorrection/8022828-8385101, http://linkedlifedata.com/resource/pubmed/commentcorrection/8022828-8431293, http://linkedlifedata.com/resource/pubmed/commentcorrection/8022828-8438592, http://linkedlifedata.com/resource/pubmed/commentcorrection/8022828-956186
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:day
5
pubmed:volume
91
pubmed:geneSymbol
CEG1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
6624-8
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
More...