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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1994-8-4
|
| pubmed:abstractText |
The most widely used medical method of terminating second-trimester pregnancy is the intravaginal administration of prostaglandin E2 (dinoprostone [PGE2]). This treatment is highly effective but is associated with severe gastrointestinal side effects and hyperpyrexia.
|
| pubmed:commentsCorrections | |
| pubmed:keyword |
http://linkedlifedata.com/resource/pubmed/keyword/Abortion, Drug Induced,
http://linkedlifedata.com/resource/pubmed/keyword/Abortion, Induced,
http://linkedlifedata.com/resource/pubmed/keyword/Americas,
http://linkedlifedata.com/resource/pubmed/keyword/Biology,
http://linkedlifedata.com/resource/pubmed/keyword/Clinical Research,
http://linkedlifedata.com/resource/pubmed/keyword/Clinical Trials,
http://linkedlifedata.com/resource/pubmed/keyword/Comparative Studies,
http://linkedlifedata.com/resource/pubmed/keyword/Developed Countries,
http://linkedlifedata.com/resource/pubmed/keyword/Endocrine System,
http://linkedlifedata.com/resource/pubmed/keyword/Family Planning,
http://linkedlifedata.com/resource/pubmed/keyword/Fertility Control, Postconception,
http://linkedlifedata.com/resource/pubmed/keyword/Misoprostol,
http://linkedlifedata.com/resource/pubmed/keyword/North America,
http://linkedlifedata.com/resource/pubmed/keyword/Northern America,
http://linkedlifedata.com/resource/pubmed/keyword/PROSTAGLANDINS,
http://linkedlifedata.com/resource/pubmed/keyword/Physiology,
http://linkedlifedata.com/resource/pubmed/keyword/Prostaglandins, Synthetic,
http://linkedlifedata.com/resource/pubmed/keyword/Research Methodology,
http://linkedlifedata.com/resource/pubmed/keyword/Research Report,
http://linkedlifedata.com/resource/pubmed/keyword/Studies,
http://linkedlifedata.com/resource/pubmed/keyword/United States
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0028-4793
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
4
|
| pubmed:volume |
331
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
290-3
|
| pubmed:dateRevised |
2010-3-24
|
| pubmed:otherAbstract |
PIP: At the Los Angeles County--University of Southern California Medical Center, physicians compared data on 27 women who received 20 mg prostaglandin E2 (PGE2) intravaginally every 3 hours to induce a 2nd trimester abortion with data on 28 similar women who received 200 mcg misoprostol intravaginally every 12 hours. The women underwent termination of pregnancy for intrauterine fetal death or medical or genetic reasons. The successful abortion rate within 24 hours was similar for both groups (81% for PGE2 and 89% for misoprostol; p = 0.47). For both groups, the mean intervals between treatment and abortion among women who successfully delivered the conceptus within 24 hours were not statistically different (10.6 hours for PGE2 and 12 hours for misoprostol; p = 0.33). Every woman in the misoprostol group successfully aborted within 38 hours. Passage of the fetus and the placenta simultaneously occurred in 32% of PGE2 cases and in 43% of misoprostol cases (p = 0.56). Women receiving PGE2 were more likely to suffer from a fever (= or 38 degrees Celsius) (63% vs. 11%; p .001), severe pain requiring analgesia medication more than once (26% vs. 4%; p = .025), vomiting (33% vs. 4%; p = .005), and diarrhea (30% vs. 4%; p = 0.012) than women receiving misoprostol. The average number of doses and the average cost per treatment were much higher for PGE2 than for misoprostol (3.7 vs. 1.4 and $315.30 vs. $0.97, respectively). 57% of misoprostol patients had a successful abortion with just 1 dose of 200 mg misoprostol. These findings demonstrate that intravaginal administration of misoprostol is a safe and effective method of terminating 2nd trimester pregnancy, easier to administer and less costly than PGE2.
|
| pubmed:meshHeading |
pubmed-meshheading:8022438-Abortion, Induced,
pubmed-meshheading:8022438-Administration, Intravaginal,
pubmed-meshheading:8022438-Adolescent,
pubmed-meshheading:8022438-Adult,
pubmed-meshheading:8022438-Costs and Cost Analysis,
pubmed-meshheading:8022438-Dinoprostone,
pubmed-meshheading:8022438-Female,
pubmed-meshheading:8022438-Humans,
pubmed-meshheading:8022438-Misoprostol,
pubmed-meshheading:8022438-Pregnancy,
pubmed-meshheading:8022438-Pregnancy Trimester, Second,
pubmed-meshheading:8022438-Prospective Studies
|
| pubmed:year |
1994
|
| pubmed:articleTitle |
A comparison of intravaginal misoprostol with prostaglandin E2 for termination of second-trimester pregnancy.
|
| pubmed:affiliation |
Department of Obstetrics and Gynecology, University of Southern California School of Medicine, Los Angeles 90033.
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Randomized Controlled Trial
|