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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
1994-8-4
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pubmed:databankReference |
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pubmed:abstractText |
The entire nucleotide sequence of a hepatitis C virus (HCV) genome (NZL1) of genotype V/3a was determined from overlapping cDNA clones obtained from a human carrier in New Zealand. It comprised 9425 nucleotides (nt) including a 5'-untranslated region of 339 nt, a single large open reading frame encoding a polyprotein of 3021 amino acids, a 3'-untranslated region of 23 nt, and 3'-terminal poly(U) stretches of variable lengths. The NZL1 genome was compared with 15 HCV isolates of other genotypes for which the full-length sequence has been determined. It differed from them by 31.1 to 34.3% in nucleotide sequence identity and by 24.5 to 29.1% in amino acid sequence identity, confirming the distinction of genotype V/3a from the other isolates.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0022-1317
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
75 ( Pt 7)
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1761-8
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:8021605-Amino Acid Sequence,
pubmed-meshheading:8021605-Base Sequence,
pubmed-meshheading:8021605-Carrier State,
pubmed-meshheading:8021605-DNA, Complementary,
pubmed-meshheading:8021605-Genes, Viral,
pubmed-meshheading:8021605-Genetic Variation,
pubmed-meshheading:8021605-Genome, Viral,
pubmed-meshheading:8021605-Genotype,
pubmed-meshheading:8021605-Hepacivirus,
pubmed-meshheading:8021605-Hepatitis C,
pubmed-meshheading:8021605-Humans,
pubmed-meshheading:8021605-Molecular Sequence Data,
pubmed-meshheading:8021605-New Zealand,
pubmed-meshheading:8021605-Nucleic Acid Conformation,
pubmed-meshheading:8021605-Open Reading Frames,
pubmed-meshheading:8021605-Phylogeny,
pubmed-meshheading:8021605-Sequence Alignment,
pubmed-meshheading:8021605-Sequence Analysis, DNA,
pubmed-meshheading:8021605-Sequence Homology, Amino Acid
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pubmed:year |
1994
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pubmed:articleTitle |
Entire nucleotide sequence and characterization of a hepatitis C virus of genotype V/3a.
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pubmed:affiliation |
First Department of Internal Medicine, Yamanashi Medical College, Japan.
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pubmed:publicationType |
Journal Article
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