|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0008633,
umls-concept:C0029016,
umls-concept:C0086282,
umls-concept:C0205314,
umls-concept:C0679622,
umls-concept:C0812270,
umls-concept:C0812380,
umls-concept:C0813971,
umls-concept:C1520990,
umls-concept:C1705691,
umls-concept:C1705694
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
1994-8-4
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|
pubmed:databankReference |
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|
pubmed:abstractText |
The v-ets oncogene family shares a conserved peptide motif called the ETS domain that mediates sequence-specific DNA binding. This motif is unique among transcription factor families. Using partially degenerate oligonucleotides from conserved regions of the ETS domain and the polymerase chain reaction, we isolated a new member of the v-ets family designated PE-1 from HL60 cells. PE-1 was expressed as an approximately 7.5-kb transcript in most cell lines tested. In the hairy cell leukemia line Eskol, there was an additional 1.8-kb transcript observed. PE-1 was the most common ETS domain gene found in CD34+HLA-DR- hematopoietic progenitors. PE-1 was localized to human chromosome 1q21-q23 using both in situ chromosomal hybridization and human-hamster hybrids.
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pubmed:grant |
|
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Mar
|
|
pubmed:issn |
0888-7543
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:day |
15
|
|
pubmed:volume |
20
|
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pubmed:geneSymbol |
PE-1,
v-ets
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
291-4
|
|
pubmed:dateRevised |
2007-11-14
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|
pubmed:meshHeading |
pubmed-meshheading:8020980-Amino Acid Sequence,
pubmed-meshheading:8020980-Blotting, Southern,
pubmed-meshheading:8020980-Cell Line,
pubmed-meshheading:8020980-Chromosome Mapping,
pubmed-meshheading:8020980-Chromosomes, Human, Pair 1,
pubmed-meshheading:8020980-DNA-Binding Proteins,
pubmed-meshheading:8020980-HeLa Cells,
pubmed-meshheading:8020980-Humans,
pubmed-meshheading:8020980-Molecular Sequence Data,
pubmed-meshheading:8020980-Multigene Family,
pubmed-meshheading:8020980-Oncogene Proteins,
pubmed-meshheading:8020980-Oncogenes,
pubmed-meshheading:8020980-Polymerase Chain Reaction,
pubmed-meshheading:8020980-Proto-Oncogene Proteins c-ets,
pubmed-meshheading:8020980-Retroviridae Proteins, Oncogenic,
pubmed-meshheading:8020980-Sequence Homology, Amino Acid,
pubmed-meshheading:8020980-Tumor Cells, Cultured
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|
pubmed:year |
1994
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|
pubmed:articleTitle |
PE-1, a novel ETS oncogene family member, localizes to chromosome 1q21-q23.
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|
pubmed:affiliation |
Department of Microbiology/Immunology, Indiana University Medical Center, Indianapolis 46202.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|
