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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1994-8-4
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pubmed:abstractText |
The use of nonsteroidal anti-inflammatory drugs (NSAIDs) is limited by their ability to induce gastrointestinal injury. Two NSAIDs were modified by incorporation of an nitroxybutyl moiety. The short-term ulcerogenic and anti-inflammatory properties of these derivatives were compared with the native NSAIDs.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0016-5085
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
107
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
173-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8020659-Animals,
pubmed-meshheading:8020659-Anti-Inflammatory Agents, Non-Steroidal,
pubmed-meshheading:8020659-Cell Adhesion,
pubmed-meshheading:8020659-Flurbiprofen,
pubmed-meshheading:8020659-Ketoprofen,
pubmed-meshheading:8020659-Leukocytes,
pubmed-meshheading:8020659-Male,
pubmed-meshheading:8020659-Nitrates,
pubmed-meshheading:8020659-Nitrites,
pubmed-meshheading:8020659-Nitrogen Oxides,
pubmed-meshheading:8020659-Platelet Aggregation,
pubmed-meshheading:8020659-Prostaglandins,
pubmed-meshheading:8020659-Rats,
pubmed-meshheading:8020659-Rats, Wistar,
pubmed-meshheading:8020659-Stomach Ulcer,
pubmed-meshheading:8020659-Structure-Activity Relationship
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pubmed:year |
1994
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pubmed:articleTitle |
Novel nonsteroidal anti-inflammatory drug derivatives with markedly reduced ulcerogenic properties in the rat.
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pubmed:affiliation |
Gastrointestinal Research Group, Faculty of Medicine, University of Calgary, Alberta, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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