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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1994-8-1
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pubmed:abstractText |
We describe the cytogenetic findings in five mucoepidermoid carcinomas (MEC) of the major and minor salivary glands. Three of the five tumors analyzed showed an apparently identical t(11;19)(q14-21;p12). In one case, the t(11;19) was the only common clonal abnormality, while in the other two cases the translocation was found together with +16, +20, and inv(1)(p32-33q42), t(6;15)(p12;q25), respectively. The latter case also showed an interstitial short arm deletion of the der(11) chromosome. Of the two remaining cases, one had a del(3)(p13p23) as the sole karyotypic abnormality, while the other had a hyperdiploid stemline characterized by the following numerical deviations: +2, +5, +6, +7, +8, +17, +18, and +19. These findings, together with previously published data from seven from seven MEC, indicate that at least two different, partially overlapping cytogenetic subgroups exist: 1) cases with structural rearrangements of 11q14-22; the finding of three tumors with an apparently identical t(11;19)(q14-21;p12) demonstrates that this is a non-random, and possibly primary abnormality in MEC, and 2) single or multiple trisomies, either observed as the sole anomalies or in combination with structural rearrangements.
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pubmed:commentsCorrections | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0165-4608
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
74
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
77-83
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8019965-Adult,
pubmed-meshheading:8019965-Aged,
pubmed-meshheading:8019965-Carcinoma, Mucoepidermoid,
pubmed-meshheading:8019965-Chromosome Aberrations,
pubmed-meshheading:8019965-Chromosomes, Human, Pair 11,
pubmed-meshheading:8019965-Female,
pubmed-meshheading:8019965-Humans,
pubmed-meshheading:8019965-In Situ Hybridization, Fluorescence,
pubmed-meshheading:8019965-Karyotyping,
pubmed-meshheading:8019965-Male,
pubmed-meshheading:8019965-Middle Aged,
pubmed-meshheading:8019965-Salivary Gland Neoplasms,
pubmed-meshheading:8019965-Translocation, Genetic,
pubmed-meshheading:8019965-Trisomy
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pubmed:year |
1994
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pubmed:articleTitle |
Recurrent rearrangements of 11q14-22 in mucoepidermoid carcinoma.
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pubmed:affiliation |
Department of Oral Pathology, University of Göteborg, Sweden.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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