Linked Life Data

8019890

Source:http://linkedlifedata.com/resource/pubmed/id/8019890

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
1994-8-3
pubmed:abstractText
Confocal laser scanning microscopy and immunofluorescence were used to detect gentamicin at the single cell level in the sensory cells of the guinea-pig hearing organ after a chronic systemic treatment. Gentamicin uptake by the hair cells precedes largely the manifestation of hearing impairment. We demonstrate that for a non-ototoxic treatment the captured gentamicin is eliminated in two phases: one rapid and one slow with approximate half-life of 2 days and 5-6 months, respectively. These novel observations should be of primary importance for new rational approaches to both the mechanism of ototoxicity and therapeutic strategies for the treatment of infectious diseases requiring the aminoglycoside antibiotics.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0764-4469
pubmed:author
pubmed:issnType
Print
pubmed:volume
316
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
682-7
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Pharmacokinetics of gentamicin in the sensory hair cells of the organ of Corti: rapid uptake and long term persistence.
pubmed:affiliation
Laboratoire d'Audiologie, Expérimentale, INSERM U 229, Université de Bordeaux-II, Hôpital Pellegrin, France.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't