Linked Life Data

8018092

Source:http://linkedlifedata.com/resource/pubmed/id/8018092

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2A
pubmed:dateCreated
1994-7-27
pubmed:abstractText
Thirteen-week toxicity of nefiracetam (N-(2,6-dimethylphenyl)-2-(2-oxo-1- pyrrolidinyl) acetamide, DM-9384, CAS 77191-36-7) was examined in rats by oral administration of 30, 120, or 480 mg/kg. Rats receiving 480 mg/kg showed salivation, prone position, increased water consumption, increased levels of serum total cholesterol, total protein, albumin and total bilirubin, increased liver weight and hypertrophy of liver cells. This hypertrophy of hepatocytes with increased liver weight was also observed in males at 120 mg/kg. The non-toxic dose of nefiracetam under the present experimental conditions was therefore determined as 30 mg/kg.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0004-4172
pubmed:author
pubmed:issnType
Print
pubmed:volume
44
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
214-6
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Thirteen-week oral toxicity study of the new cognition-enhancing agent nefiracetam in rats.
pubmed:affiliation
Drug Safety Research Center, Developmental Research Laboratories, Daiichi Pharmaceutical Co., Ltd., Tokyo, Japan.
pubmed:publicationType
Journal Article